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This Year In Medicine 2025

Opinion|Podcasts|November 8, 2024

Role of Testing in CSU Diagnosis

Author(s)David Khan, MD , Kristin Sokol, MD , Vivian Hernandez-Trujillo, MD

Key Takeaways

Routine blood tests, such as ESR, CRP, IgG anti-TPO, and total IgE, are recommended for diagnosis.
Biopsy is generally not required for diagnostic testing in this context.
Disease severity is assessed using UAS7 and UCT, evaluating symptom frequency, intensity, and control.

SHOW MORE

Panelists discuss the recommended diagnostic testing for chronic spontaneous urticaria (CSU), noting that extensive testing is not necessary and that routine blood counts, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), IgG anti-thyroid peroxidase (TPO), and total IgE are adequate, while also addressing the limited role of biopsy; they further explore how disease severity is assessed using tools like Urticaria Activity Score (UAS7) and Urticaria Control Test (UCT).

Episodes in this series

EP. 1 Overview of CSU: Prevalence and Presentations

EP. 1 Overview of CSU: Prevalence and Presentations

EP. 2 Impact of CSU on Patient Quality of Life

EP. 2 Impact of CSU on Patient Quality of Life

EP. 3 Pathophysiology of CSU and Role of BTK

EP. 3 Pathophysiology of CSU and Role of BTK

EP. 4 Diagnostic Approach to CSU

EP. 4 Diagnostic Approach to CSU

EP. 5 Role of Testing in CSU Diagnosis

EP. 5 Role of Testing in CSU Diagnosis

EP. 6 Referring CSU Patients to a Specialist

EP. 6 Referring CSU Patients to a Specialist

EP. 7 Treatment Goals and Guidelines for CSU

EP. 7 Treatment Goals and Guidelines for CSU

EP. 8 Role of Antihistamines, Steroids and Biologics in Treating CSU

EP. 8 Role of Antihistamines, Steroids and Biologics in Treating CSU

EP. 9 Challenges With Current Treatment Options for CSU

EP. 9 Challenges With Current Treatment Options for CSU

EP. 10 Future Landscape of BTK Inhibitors for CSU

EP. 10 Future Landscape of BTK Inhibitors for CSU

EP. 11 Patient Education Tips for CSU and Final Thoughts

EP. 11 Patient Education Tips for CSU and Final Thoughts

Video content above is prompted by the following:

Is testing recommended for diagnosis, and if so, which kind?
- Extensive testing not needed: routine blood count. ESR and/or CRP, and IgG anti-TPO and total IgE (according to guidelines)
- What is the role, if any, of biopsy in diagnostic testing?
How is disease severity assessed?
- UAS7
- UCT

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