Asthma Patients Require Increased Detection of Dysfunctional Breathing
Dysfunctional breathing is a common comorbidity in patients with severe asthma, and is associated with increased patient anxiety and depression.
Novel CompEx Endpoint Could Improve Asthma Therapy Assessments
CompEx combines deteriorations and frequency of asthma exacerbations that are recorded twice daily by patients. An algorithm is developed based off of patient deterioration below threshold limits.
Blood Eosinophil Increase Can Predict Asthma Lung Function Decline
Close to half of observed patients had severe asthma and uncontrolled even with high doses of ICS or LABA. Among them, more than half had the eosinophilic inflammatory phenotype.
FeNO Test Shows Promise in Detecting Polyps in Asthma Patients
Approximately one-half of patients with chronic rhinosinusitis with nasal polyposis have asthma. The less-invasive FeNO test may help detect comorbid patients.
Asthma Patients Continue to Misuse Inhaler Therapy, Despite Guidelines
Research has shown that few children with asthma correctly use their inhalers, despite guidelines explicitly stating that each physician visit should include review of inhaler technique and use of devices.
Patients with Lower Eosinophil Counts Can Still Benefit from Mepolizumab
The injectable IL-5 inhibitor therapy is more commonly recommended for patients with greater eosinophil counts.
Largest, Diverse Genome-Wide Association Study Links Loci to Asthma Risk
A 68,000-plus patient study could lead to new therapies, more complete and efficient ways to diagnose asthma, and help identify environmental factors that protect against it.
ACT Scores Fail to Predict Asthma Exacerbations
Six-month ACT, lung function, exacerbation rate scores showed no correlation between exacerbations and the standard for patient scoring.
Maternal Asthma Linked to Postpartum Depression Risk
Pregnant women who suffer from asthma reported a two-fold greater risk for PPD according to the results of a large-scale Quebec hospital cohort.
Study: Elevated Sex Hormone-Binding Globulin Protects Against Asthma
SHBG is present in about 9.7% of adult women who have asthma, and 5.4% of adult men with asthma.
Omega-3 Fatty Acid Aids Asthma Symptoms, While Omega-6 Aggravates
Investigators believe this is the first study to show both the omega-3 protective effect and deleterious effect of omega-6 on indoor particular matter exposure and systemic inflammation.
Study: Poor Maternal Nutrition Linked to Pulmonary Dysfunction
Investigators found in animal models that pulmonary endothelial function was influenced by caloric intake rates.
Forthcoming Study Will Assess Fiber Intake on Asthma Symptoms
The study will focus on a dozen-plus children with severe asthma over a period of 4 weeks.
Study Links Infant Bronchiolitis to Later Respiratory Illness
Largest birth cohort study to date strengthens link between infant bronchiolitis and later respiratory disease.
Study Finds Distinct Damage in Explanted Lung Tissue of PH-COPD Patients
Little is known on the underlying pulmonary arterial lesions in patients with this phenotype of COPD.
Asthma Patient Performance Enhanced by Rapid Benralizumab Response
According to investigators, recent trial results indicate no other biologic treatment has shown as rapid onset than benralizumab for patients with eosinophilic asthma.
Long-Term Allergy Immunotherapy Shows Years-Long Tolerance Retention
About 9 of 10 patients were able to safely consume foods containing peanuts in an eight-year, longitudinal observational study.
New Peptide Therapy Lowers Severe Allergic Reactions Risk
Investigative therapy PVX108 showed a favorable tolerability and safety profile in patients with peanut allergies.
Heated Tobacco Products Cause Similar Cell Inflammation to Combustible Cigarettes
Asthma risk and lung disease development can occur as easily and as frequently with smoking alternatives as it does with combustible cigarettes.
Testosterone Shown to Impact Lung Function, Could Influence Asthma Care
Both sex- and age-specific therapies could come to clinical asthma field in upcoming years.
Common E-Cigarette Flavorings Linked to Weakened Cilia in Lungs
Harvard University investigators found that both diacetyl and 2,3-pentanedione initiated changes in gene expressions that reduced the number of ciliated cells, and impacted how well they functioned.
COPD Over-Diagnosis Results in Adverse Treatment Effects
Only a few studies have examined over-diagnosis, which investigators note is common if the diagnosis is based on symptoms alone or on a pre-bronchodilator spirometry.
African Americans Less Likely To Obtain Outpatient Asthma Care
Recent research suggests African Americans have a asthma-related mortality rate 10 times greater than non-Hispanic white children.
About 20% of New York City Teenagers Have Undiagnosed Asthma
Among differing genders and races, Columbia University investigators found females and Asian Americans are the most at-risk to have the undiagnosed condition.
Treating Vitamin D Deficiencies Could Curb COPD Exacerbation
Meta-analysis of other randomized controlled trials have shown that vitamin D supplementation reduces the risk of acute respiratory infections and exacerbations of asthma.
Secondhand E-Cig Vapors May Cause Asthma Exacerbations
A recent study found a link between electronic nicotine delivery systems and asthma symptoms.
Alternatives Needed for Evaluating RSV Vaccine Impact on Asthma, Wheeze
Candidate vaccines for respiratory syncytial virus may also impact pediatric asthma and wheezing, but the required sample sizes are too large for a clinical trial.
New Tool Better Predicts Pediatric Asthma Development
The Pediatric Asthma Risk Score could improve on the track record of the Asthma Predictive Index, which in the past has been shown to poorly predict who would develop the condition.
Genetic Variants Linked to Asthma, Mucus Production
UK investigators conducted the first large study seeking to understand whether the same or different genes explain why some people experience more severe asthma symptoms.
Multiple Food Allergies Associated with Worsened Pediatric Lung Function
Children often develop food allergies prior to developing asthma, and the former condition is associated with a greater risk of the latter condition in later life.
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