Carisa D. Brewster

Dysfunctional breathing is a common comorbidity in patients with severe asthma, and is associated with increased patient anxiety and depression.

CompEx combines deteriorations and frequency of asthma exacerbations that are recorded twice daily by patients. An algorithm is developed based off of patient deterioration below threshold limits.

Close to half of observed patients had severe asthma and uncontrolled even with high doses of ICS or LABA. Among them, more than half had the eosinophilic inflammatory phenotype.

Approximately one-half of patients with chronic rhinosinusitis with nasal polyposis have asthma. The less-invasive FeNO test may help detect comorbid patients.

Research has shown that few children with asthma correctly use their inhalers, despite guidelines explicitly stating that each physician visit should include review of inhaler technique and use of devices.

The injectable IL-5 inhibitor therapy is more commonly recommended for patients with greater eosinophil counts.

A 68,000-plus patient study could lead to new therapies, more complete and efficient ways to diagnose asthma, and help identify environmental factors that protect against it.

Six-month ACT, lung function, exacerbation rate scores showed no correlation between exacerbations and the standard for patient scoring.

Pregnant women who suffer from asthma reported a two-fold greater risk for PPD according to the results of a large-scale Quebec hospital cohort.

SHBG is present in about 9.7% of adult women who have asthma, and 5.4% of adult men with asthma.

Investigators believe this is the first study to show both the omega-3 protective effect and deleterious effect of omega-6 on indoor particular matter exposure and systemic inflammation.

Investigators found in animal models that pulmonary endothelial function was influenced by caloric intake rates.

The study will focus on a dozen-plus children with severe asthma over a period of 4 weeks.

Largest birth cohort study to date strengthens link between infant bronchiolitis and later respiratory disease.

Little is known on the underlying pulmonary arterial lesions in patients with this phenotype of COPD.

According to investigators, recent trial results indicate no other biologic treatment has shown as rapid onset than benralizumab for patients with eosinophilic asthma.

About 9 of 10 patients were able to safely consume foods containing peanuts in an eight-year, longitudinal observational study.

Investigative therapy PVX108 showed a favorable tolerability and safety profile in patients with peanut allergies.

Asthma risk and lung disease development can occur as easily and as frequently with smoking alternatives as it does with combustible cigarettes.

Both sex- and age-specific therapies could come to clinical asthma field in upcoming years.

Harvard University investigators found that both diacetyl and 2,3-pentanedione initiated changes in gene expressions that reduced the number of ciliated cells, and impacted how well they functioned.

Only a few studies have examined over-diagnosis, which investigators note is common if the diagnosis is based on symptoms alone or on a pre-bronchodilator spirometry.

Recent research suggests African Americans have a asthma-related mortality rate 10 times greater than non-Hispanic white children.

Among differing genders and races, Columbia University investigators found females and Asian Americans are the most at-risk to have the undiagnosed condition.

Meta-analysis of other randomized controlled trials have shown that vitamin D supplementation reduces the risk of acute respiratory infections and exacerbations of asthma.

A recent study found a link between electronic nicotine delivery systems and asthma symptoms.

Candidate vaccines for respiratory syncytial virus may also impact pediatric asthma and wheezing, but the required sample sizes are too large for a clinical trial.

The Pediatric Asthma Risk Score could improve on the track record of the Asthma Predictive Index, which in the past has been shown to poorly predict who would develop the condition.

UK investigators conducted the first large study seeking to understand whether the same or different genes explain why some people experience more severe asthma symptoms.

Children often develop food allergies prior to developing asthma, and the former condition is associated with a greater risk of the latter condition in later life.