Asthma

These data highlighted new findings on the experiences of children aged 6 to 11 with uncontrolled type 2 asthma treated with dupilumab.

New research presented at ASRS 2024 links maternal asthma to a higher risk of advanced retinopathy of prematurity.

These findings also highlighted the necessity of identifying the clinically relevant comorbidities of asthma and allergic rhinitis in a proactive manner.

The panel offers their final recommendations for physicians managing patients with asthma.

The panel discusses the biologic drugs approved for use in children with asthma, including omalizumab, dupilumab, mepolizumab, and the recently approved benralizumab. They share their preferences among these options for improving lung function in pediatric patients.

Robert Sporter, MD, discusses the initial conversations he has with pediatric patients and their parents when considering biologic therapies, addressing the risks associated with not treating the condition, such as compromised lung function and increased steroid use. He emphasizes the importance of communicating a comprehensive treatment plan, including contingencies for cases where a particular therapy may not be effective.

Shahzad Mustafa, MD, examines the pediatric atopic march, a phenomenon characterized by the sequential development of wheezing, asthma, and food allergies in children, discussing the progression and interrelationship of these conditions. He also explores the potential benefits of early intervention with medications in managing these conditions in pediatric patients.

Robert Sporter, MD, explores the differences in treatment approaches between adult and pediatric populations, focusing on allergy-based asthma treatments such as allergen immunotherapy and biologics, and their specific applications in managing asthma in children.

Medical experts discuss eligibility criteria for biologic therapies, noting that biologics can be used for other allergies and in patients with comorbidities, highlighting the potential for these targeted treatments to benefit a broad age range of patients.

Sande Okelo, MD, leads a discussion on the updates in the GINA 2021 report regarding difficult-to-treat and severe asthma, as well as considerations for GINA Step 4 and 5 treatment approaches.

The expert panel discusses the use of biologics in treating asthma, explaining their mechanisms of action, differences, and target populations, while also examining trends in long-term efficacy and safety for patients with severe or uncontrolled asthma.

The key opinion leaders explore the utilization of biomarkers in guiding the treatment of severe or uncontrolled asthma, discussing the specific role of eosinophils in informing therapeutic decision-making for patients with challenging asthma cases.

Sande Okelo, MD, outlines the factors that contribute to the overuse of oral corticosteroids (OCS), such as nonadherence, poor inhaler technique, inappropriate prescription, and comorbidities, while also discussing strategies to limit OCS overuse and acknowledging that undertreatment can also be a significant issue.

The panel addresses the issue of patients being exposed to high levels of oral corticosteroids (OCS) without realizing it, as various prescribers can administer steroids. They also discuss the essential questions healthcare professionals should ask to comprehend a patient's total OCS exposure and provide a definition of high OCS use.

The key opinion leaders deliberate on the criteria used to classify a patient as having moderate or severe asthma, as well as the factors that determine when a patient's asthma is deemed uncontrolled—including the use of combination therapy and daily symptoms.

The panelists explore the significance of type 2 inflammation in asthma, including its role and associated markers, while also delving into their approach to assessing patients whose asthma is triggered or worsened by allergies, examining markers beyond IgE and noting the frequency of patients presenting with asthma symptoms during allergy season without actually having allergic asthma.

S Shahzad Mustafa, MD, discusses various asthma endotypes and phenotypes, considering factors such as race, age of onset, gender, BMI, and lung function test results.

Nicole Chase, MD; S Shahzad Mustafa, MD; Sande Okelo, MD, and Robert Sporter, MD, examine the distinct manifestations of asthma stemming from allergic and non-allergic origins, as well as the factors contributing to its exacerbation.

Lovinsky-Desir joins Lungcast on World Asthma Day to discuss community-specific burdens of disease, and emerging strategies to manage it.

Balmes discusses the latest annual State of the Air Report, which shows that 131 million Americans are living in areas with failing air quality grades.

This analysis looked at the potential connection between SARS-CoV-2 test positivity and new asthma diagnoses.

The FDA approval of benralizumab for patients ages 6 to 11 with asthma follows the conclusions of the phase 3 TATE study.

This analysis highlights trends following the significant update made to the Global Initiative for Asthma and the National Heart Lung and Blood Institute asthma guidelines.

In this new research, different populations of Black and Latinx individuals are facing long-term impacts of air pollution in the city of Austin.

On March 07, 2024, Boehringer Ingelheim announced it would be instituting a $35 per month out-of-pocket cost cap for its portfolio of inhaler products, with this cap going into effect on June 01, 2024.