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A 59-year-old woman presented to clinic for evaluation of multiple moles. Although the moles were not suspicious on physical exam, she was noted to have bilateral deformities of her thumb nails. Her past medical history is significant for chronic knee pain and breast cancer that was successfully treated 13 years ago. What is your diagnosis?

Several factors should be considered when choosing a medication and dosing schedule for this depressed adult male who reports being "very sensitive" to medication and expresses particular concern about being either sedated or "revved up" from an antidepressant.

This 44-year-old man presented to a clinic with multiple dark lesions on his lower extremities. When the lesions first appeared eight months ago, they were slightly raised, pink in color, and intensely itchy, but after repeated excoriation, they have become increasingly dark. The patient reports that a biopsy was inconclusive and creams and an oral medication have not helped his condition. In addition to his leg lesions, there is some involvement of the thigh, buttocks, and penis. He denies any past medical history or other medications. What condition does this man have?