Gastroenterology

There was no significant difference in performance between the model with only bile acids compared to models with bile acids and clinical variables.

Hematopoietic stem cell transplant is generally associated with increased C difficile infection risk.

Sustained virologic response following direct acting antiviral treatment substantially reduced the all-cause mortality rate in patients with HCV.

More than half of the patients in the study were treated for inflammatory bowel disease with infliximab.

The expansion for sofosbuvir/velpatasvir is supported by phase 2 data showing an 83% sustained virologic response or cure rate among patients as young as 3 years old.

Patients included in the study had a median of 3 prior CDI episodes and 4 risk factors for recurrent infections.

The UNITI studies have shown ustekinumab is effective at inducing and maintaining clinical remission in Crohn’s disease patients.

Using both tests to screen for colorectal cancer was more effective than just using colonoscopies alone.

Direct-acting antivirals has increased the need to treat children HCV patients before they begin to engage in dangerous behaviors.

Vedolizumab treatment was associated with lower IMC recurrence rate after ICI resumption.

Seres expects to move forward with plans for SER-109 as a novel treatment for CDI.

More patients treated with risankizumab 360 mg achieved clinical remission than the induction-only control group.

Patients treated with ustekinumab had significantly more prior biologic use than patients treated with vedolizumab.

Data show low BMI, male gender, and older age in patients associated with higher overall mortality.

The treatment is also being studied for safety and efficacy in patients with Crohn’s disease.

Multiple studies have found a decrease in CDI rates during the COVID-19 pandemic in comparison to previous years.

Specialist intervention is likely not necessary for low-risk patients; and so, non-liver specialists can be reassured of G/P’s safety profile.

Esophageal cancer has a low survival rate largely due to advanced stage diagnosis.

Nearly two-thirds of patients had improved or resolved EIM after ustekinumab treatment.

A large proportion of IBS-C patients did not seek health care during the COVID-19 pandemic despite symptoms.

Arena Pharmaceuticals expects to move forward with later phase clinical trials testing etrasimod.

Patients with opioid-induced constipation had more frequent, painful constipation symptoms, compared to those with chronic idiopathic constipation.

Direct optical endoscopy are often underutilized in screenings for EAC.

Data show patients with IBD and pathogen produced a unique pathogen-specific microbiome.

Dr. Evan Dellon said up to 8 biopsies for high risk patients could be beneficial in diagnosing different diseases impacting the esophagus.