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Spotlight -

This Year In Medicine 2025

Opinion|Videos|July 2, 2024

Current Hepatic Encephalopathy Therapies Targeting Gut-Liver Axis Disturbance

Author(s)Pamela Kushner, MD, FAAFP , Nancy Reau, MD, Arun Jesudian, MD

Nancy Reau, MD, leads a discussion on the current abnormality-targeting agents used to prevent and treat hepatic encephalopathy (HE) by addressing the gut-liver axis, specifically focusing on lactulose or lactitol and rifaximin, while also explaining their mechanisms of action and adverse event profiles.

Episodes in this series

Video 1 - 4 KOLs are featured in, "Exploring the Impact of Hepatic Encephalopathy on Patients and Their Families "

EP. 1 Exploring the Impact of Hepatic Encephalopathy on Patients and Their Families

Video 2 - 4 KOLs are featured in, "Educating Primary Care Clinicians on Outpatient HE Management and Ammonia Testing"

EP. 2 Educating Primary Care Clinicians on Outpatient HE Management and Ammonia Testing

Video 3 - 4 KOLs are featured in, "HE Experts on Symptoms, Risk Factors, Diagnosis Challenges, and Severity Grading"

EP. 3 HE Experts on Symptoms, Risk Factors, Diagnosis Challenges, and Severity Grading

Video 3 - 4 KOLs are featured in, "Collaborating with Specialists: Primary Care Clinician’s Evolving Role in HE Management"

EP. 4 Collaborating with Specialists: Primary Care Clinician’s Evolving Role in HE Management

4 KOLs are featured in this series

EP. 5 Preventing Cirrhosis Progression: Gut-Liver Axis, Circulation, Inflammation

4 KOLs are featured in this series

EP. 6 Hepatic Encephalopathy: Exploring Alterations in Microbiota Caused by Liver Disease

4 KOLs are featured in this series

EP. 7 Current Hepatic Encephalopathy Therapies Targeting Gut-Liver Axis Disturbance

4 KOLs are featured in this series

EP. 8 AASLD Guidelines for Hepatic Encephalopathy: Rifaximin's Role and Safety

4 KOLs are featured in this series

EP. 9 Overview of Outpatient Strategies for Optimizing Patient Outcomes in HE

4 KOLs are featured in this series

EP. 10 Managing Adverse Effects in HE Treatment

4 KOLs are featured in this series

EP. 11 Practical Tips for the Primary Care Clinician Treating HE

4 KOLs are featured in this series

EP. 12 Refractory Encephalopathy, Multivitamins and Closing Thoughts

Which agents do we have to target abnormalities in gut-liver axis to prevent and treat HE? (lactulose or lactitol, rifaximin) Sanchez-Delgado et al 2016
- What is the mechanism of action of these therapies?
- What is their tolerability and their side effect profile?

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