Hepatic Encephalopathy: Exploring Alterations in Microbiota Caused by Liver Disease

Author(s):

Pamela Kushner, MD, FAAFP ,Nancy Reau, MD

Kimberly Brown, MD, explains the role of the gut microbiota in the development of hepatic encephalopathy (HE) and describes the common alterations to the microbiota that occur because of chronic liver disease.

EP: 1.Exploring the Impact of Hepatic Encephalopathy on Patients and Their Families

EP: 2.Educating Primary Care Clinicians on Outpatient HE Management and Ammonia Testing

EP: 3.HE Experts on Symptoms, Risk Factors, Diagnosis Challenges, and Severity Grading

EP: 4.Collaborating with Specialists: Primary Care Clinician’s Evolving Role in HE Management

EP: 5.Preventing Cirrhosis Progression: Gut-Liver Axis, Circulation, Inflammation

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EP: 6.Hepatic Encephalopathy: Exploring Alterations in Microbiota Caused by Liver Disease

EP: 7.Current Hepatic Encephalopathy Therapies Targeting Gut-Liver Axis Disturbance

EP: 8.AASLD Guidelines for Hepatic Encephalopathy: Rifaximin's Role and Safety

EP: 9.Overview of Outpatient Strategies for Optimizing Patient Outcomes in HE

EP: 10.Managing Adverse Effects in HE Treatment

EP: 11.Practical Tips for the Primary Care Clinician Treating HE

EP: 12.Refractory Encephalopathy, Multivitamins and Closing Thoughts

Can you please explain the role of the gut microbiota in the pathogenesis of HE?
- What are the gut microbiome changes seen in chronic liver disease (CLD)?
- Does this vary in different stages of CLD?