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Spotlight -

This Year In Medicine 2025

Opinion|Videos|March 17, 2025

ECZTEND 2-Year Interim Findings: Takeaways and Considerations

Author(s)Brad P. Glick, DO, MPH, Zed Zha, MD, FAAFP, Charles Vega, MD, FAAFP

Panelists discuss how the 2-year ECZTEND study found tralokinumab effective for atopic dermatitis, with 82.5% achieving EASI-75 and 59.8%, EASI-90. Common adverse effects (AEs) included upper respiratory tract infections, dermatitis, headache, and conjunctivitis. The treatment-emergent adverse event (TEAE) withdrawal rate was 1.6%.

Episodes in this series

EP. 1 Frontline Management of Atopic Dermatitis in Adults

EP. 1 Frontline Management of Atopic Dermatitis in Adults

5 experts in this video

EP. 2 Considerations for Diagnosis of Atopic Dermatitis in Adults

5 experts in this video

EP. 3 A Primary Care Perspective on Diagnosing Atopic Dermatitis

5 experts in this video

EP. 4 Strategies for Determining Severity of Atopic Dermatitis

5 experts in this video

EP. 5 Collaboration Between Primary Care and Dermatology in Atopic Dermatitis Care

5 experts in this video

EP. 6 The Utility of Newer Topical Therapies for Atopic Dermatitis

5 experts in this video

EP. 7 The Impact of Biologics on a Changing Atopic Dermatitis Treatment Landscape

5 experts in this video

EP. 8 A Primary Care Perspective on Newer-Generation Systemic Therapies

5 experts in this video

EP. 9 Safety of Systemic Agents in Atopic Dermatitis Management

5 experts in this video

EP. 10 LIBERTY AD Open-Label Extension Analysis: Takeaways and Considerations

5 experts in this video

EP. 11 ECZTEND 2-Year Interim Findings: Takeaways and Considerations

5 experts in this video

EP. 12 Rapid Efficacy and Safety Considerations With the Use of JAK Inhibitors in Atopic Dermatitis Care

5 experts in this video

EP. 13 Safety Protocols With JAK Inhibitors

5 experts in this video

EP. 14 JADE COMPARE: Considerations for Comparisons Among Systemic Agents in Atopic Dermatitis

5 experts in this video

EP. 15 Evaluation of Long-Term Data With JAK Inhibitors

5 experts in this video

EP. 16 Clinical Considerations for Choosing a Systemic Agent for Patients With Atopic Dermatitis

5 experts in this video

EP. 17 Multispecialty Perspectives on Shared Decision-Making in Atopic Dermatitis Care

5 experts in this video

EP. 18 Future Directions in the Management Atopic Dermatitis in Adult Patients

Video content above in prompted by the following:

Based on the 2-year interim findings from the ECZTEND study (tralokinumab) (Blauvelt 2022), in what circumstances would you consider tralokinumab?
Of the 291 subjects who remained in the trial for 2 years, 82.5% achieved EASI-75, and 59.8% achieved EASI-90.
In the 1-year safety study, the most common AEs were upper respiratory tract infections, atopic dermatitis, headache, and conjunctivitis.
19/1174 (1.6%) withdrew due to TEAEs.

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Rachel N. Grisham, MD

Community Collab™: Identifying the Role of Complement Inhibitors in the Management of Generalized Myasthenia Gravis

Community Collab™: Identifying the Role of Complement Inhibitors in the Management of Generalized Myasthenia Gravis

James F. Howard Jr, MD, FAAN; Tuan Vu, MD

From Gene to Gut: Understanding TL1A’s Function in IBD Evolution

From Gene to Gut: Understanding TL1A’s Function in IBD Evolution

Jordan E. Axelrad, MD, MPH, FACG

From Gene to Gut: Understanding TL1A’s Function in IBD Evolution

From Gene to Gut: Understanding TL1A’s Function in IBD Evolution

Jordan E. Axelrad, MD, MPH, FACG

Overcoming Barriers to Long-Acting Injectable Agents in Schizophrenia

Overcoming Barriers to Long-Acting Injectable Agents in Schizophrenia

Patricia Junquera, MD; Maria Collado, MD; Erin C. Crown, MHSPAS, PA-C, Psych-CAQ

Community Collab: The Evolving Role of FcRN Inhibitors in the Management of Generalized Myasthenia Gravis (gMG)

Community Collab: The Evolving Role of FcRN Inhibitors in the Management of Generalized Myasthenia Gravis (gMG)

James F. Howard Jr, MD, FAAN; Tuan Vu, MD

The Presbyopia-Correcting and Toric IOL Playbook: Game-Changing Surgical Strategies to Enhance Patient Outcomes

The Presbyopia-Correcting and Toric IOL Playbook: Game-Changing Surgical Strategies to Enhance Patient Outcomes

Uday Devgan, MD, FACS, FRCS

Expert Illustrations & Commentary: Visualizing Novel Therapeutic Targets for Patients with Major Depressive Disorder

Expert Illustrations & Commentary: Visualizing Novel Therapeutic Targets for Patients with Major Depressive Disorder

Juan D. Oms, MD, FAPA; Linda Collado, MD, DABPN, FAPA; Ginger Shupe, MD

Cases and Conversations™: Navigating CKD and Heart Failure in T1D and T2D—Applying the Latest Guidelines and Evidence

Cases and Conversations™: Navigating CKD and Heart Failure in T1D and T2D—Applying the Latest Guidelines and Evidence

Stephen J Greene, MD; Anuradha Lala-Trindade, MD

Advances in™: Lipoprotein(a) as a Target for ASCVD Risk Reduction – Updates for Clinical Practice

Advances in™: Lipoprotein(a) as a Target for ASCVD Risk Reduction – Updates for Clinical Practice

Pam R. Taub, MD, FACC, FASPC; Payal Kohli, MD, FACC

When Mites Meet Their Match: Empowering Patients With Targeted Treatment for 𝘋𝘦𝘮𝘰𝘥𝘦𝘹 Blepharitis

When Mites Meet Their Match: Empowering Patients With Targeted Treatment for 𝘋𝘦𝘮𝘰𝘥𝘦𝘹 Blepharitis

Mile Brujic, OD, FAAO; Pierce Kenworthy, OD, FAAO; Blair Lonsberry, MS, OD, MEd, FAAO

Burst CME™: Burden of Sickle Cell Disease

Burst CME™: Burden of Sickle Cell Disease

Matthew Heeney, MD; Biree Andemariam, MD

Burst CME™: Burden of Sickle Cell Disease

Burst CME™: Burden of Sickle Cell Disease

Matthew Heeney, MD; Biree Andemariam, MD

Burst CME™: Recognizing Lupus Nephritis—From Timely Diagnosis to Appreciating the Underlying Mechanisms of Disease

Burst CME™: Recognizing Lupus Nephritis—From Timely Diagnosis to Appreciating the Underlying Mechanisms of Disease

Michelle Petri, MD, MPH; Shivani Garg, MD, PhD

Burst CME™: Recognizing Lupus Nephritis—From Timely Diagnosis to Appreciating the Underlying Mechanisms of Disease

Burst CME™: Recognizing Lupus Nephritis—From Timely Diagnosis to Appreciating the Underlying Mechanisms of Disease

Michelle Petri, MD, MPH; Shivani Garg, MD, PhD

Bridging Regional Challenges in Retinal Disease Management: Applying Advanced Anti-VEGF Therapy in Community Practice - Florida

Bridging Regional Challenges in Retinal Disease Management: Applying Advanced Anti-VEGF Therapy in Community Practice - Florida

Carl J. Danzig, MD, FASRS

The Rise of Novel HER2-Targeting Therapies in GEA: Mechanisms and Clinical Data

The Rise of Novel HER2-Targeting Therapies in GEA: Mechanisms and Clinical Data

Rahul Gosain, MD, MBA; Rohit Gosain, MD

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Screening and Diagnosis of Hypercortisolism in Type 2 Diabetes

Prevalence and Recognition of Hypercortisolism

Distinguishing CSU From Chronic Inducible Urticaria Subtypes

Diagnosing the Hallmark Signs and Symptoms of CSU

METRE-PL Data Shows Severe Metabolic Disease Burden in FPLD Despite Standard Therapy