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Spotlight -

This Year In Medicine 2025

Opinion|Videos|March 17, 2025

LIBERTY AD Open-Label Extension Analysis: Takeaways and Considerations

Author(s)Brad P. Glick, DO, MPH, Zed Zha, MD, FAAFP, Charles Vega, MD, FAAFP

Panelists discuss how The LIBERTY AD OLE study (Beck 2024) showed sustained efficacy of treatment in atopic dermatitis, with 96.9% achieving EASI-50; 88.9%, EASI-75; and 80.7%, EASI-90 over 260 weeks. Common adverse events (AEs) included nasopharyngitis, atopic dermatitis (AD) worsening, upper respiratory tract infections, herpes infections, and conjunctivitis. Treatment-emergent adverse event (TEAE)–related withdrawal was 3.8%.

Episodes in this series

EP. 1 Frontline Management of Atopic Dermatitis in Adults

EP. 1 Frontline Management of Atopic Dermatitis in Adults

5 experts in this video

EP. 2 Considerations for Diagnosis of Atopic Dermatitis in Adults

5 experts in this video

EP. 3 A Primary Care Perspective on Diagnosing Atopic Dermatitis

5 experts in this video

EP. 4 Strategies for Determining Severity of Atopic Dermatitis

5 experts in this video

EP. 5 Collaboration Between Primary Care and Dermatology in Atopic Dermatitis Care

5 experts in this video

EP. 6 The Utility of Newer Topical Therapies for Atopic Dermatitis

5 experts in this video

EP. 7 The Impact of Biologics on a Changing Atopic Dermatitis Treatment Landscape

5 experts in this video

EP. 8 A Primary Care Perspective on Newer-Generation Systemic Therapies

5 experts in this video

EP. 9 Safety of Systemic Agents in Atopic Dermatitis Management

5 experts in this video

EP. 10 LIBERTY AD Open-Label Extension Analysis: Takeaways and Considerations

5 experts in this video

EP. 11 ECZTEND 2-Year Interim Findings: Takeaways and Considerations

5 experts in this video

EP. 12 Rapid Efficacy and Safety Considerations With the Use of JAK Inhibitors in Atopic Dermatitis Care

5 experts in this video

EP. 13 Safety Protocols With JAK Inhibitors

5 experts in this video

EP. 14 JADE COMPARE: Considerations for Comparisons Among Systemic Agents in Atopic Dermatitis

5 experts in this video

EP. 15 Evaluation of Long-Term Data With JAK Inhibitors

5 experts in this video

EP. 16 Clinical Considerations for Choosing a Systemic Agent for Patients With Atopic Dermatitis

5 experts in this video

EP. 17 Multispecialty Perspectives on Shared Decision-Making in Atopic Dermatitis Care

5 experts in this video

EP. 18 Future Directions in the Management Atopic Dermatitis in Adult Patients

Video content above in prompted by the following:

Can you discuss the notable findings from the LIBERTY AD OLE study (Beck 2024) and how they are relevant to you and your practice?
Of the 326 subjects who remained in the trial for 260 weeks, 96.9% achieved EASI-50; 88.9%, EASI-75; and 80.7%, EASI-90.
Most common AEs were nasopharyngitis, worsening AD, upper respiratory tract infection, herpes viral infections, and conjunctivitis
101/2677 (3.8%) of patients in the safety analysis set withdrew due to TEAEs.

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SimulatEd™: A Roadmap to Personalized Care Plans and Shared Decision-Making in Low-Grade Serous Ovarian Cancer

Rachel N. Grisham, MD

Community Collab™: Identifying the Role of Complement Inhibitors in the Management of Generalized Myasthenia Gravis

Community Collab™: Identifying the Role of Complement Inhibitors in the Management of Generalized Myasthenia Gravis

James F. Howard Jr, MD, FAAN; Tuan Vu, MD

From Gene to Gut: Understanding TL1A’s Function in IBD Evolution

From Gene to Gut: Understanding TL1A’s Function in IBD Evolution

Jordan E. Axelrad, MD, MPH, FACG

From Gene to Gut: Understanding TL1A’s Function in IBD Evolution

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Jordan E. Axelrad, MD, MPH, FACG

Overcoming Barriers to Long-Acting Injectable Agents in Schizophrenia

Overcoming Barriers to Long-Acting Injectable Agents in Schizophrenia

Patricia Junquera, MD; Maria Collado, MD; Erin C. Crown, MHSPAS, PA-C, Psych-CAQ

Community Collab: The Evolving Role of FcRN Inhibitors in the Management of Generalized Myasthenia Gravis (gMG)

Community Collab: The Evolving Role of FcRN Inhibitors in the Management of Generalized Myasthenia Gravis (gMG)

James F. Howard Jr, MD, FAAN; Tuan Vu, MD

The Presbyopia-Correcting and Toric IOL Playbook: Game-Changing Surgical Strategies to Enhance Patient Outcomes

The Presbyopia-Correcting and Toric IOL Playbook: Game-Changing Surgical Strategies to Enhance Patient Outcomes

Uday Devgan, MD, FACS, FRCS

Expert Illustrations & Commentary: Visualizing Novel Therapeutic Targets for Patients with Major Depressive Disorder

Expert Illustrations & Commentary: Visualizing Novel Therapeutic Targets for Patients with Major Depressive Disorder

Juan D. Oms, MD, FAPA; Linda Collado, MD, DABPN, FAPA; Ginger Shupe, MD

Cases and Conversations™: Navigating CKD and Heart Failure in T1D and T2D—Applying the Latest Guidelines and Evidence

Cases and Conversations™: Navigating CKD and Heart Failure in T1D and T2D—Applying the Latest Guidelines and Evidence

Stephen J Greene, MD; Anuradha Lala-Trindade, MD

Advances in™: Lipoprotein(a) as a Target for ASCVD Risk Reduction – Updates for Clinical Practice

Advances in™: Lipoprotein(a) as a Target for ASCVD Risk Reduction – Updates for Clinical Practice

Pam R. Taub, MD, FACC, FASPC; Payal Kohli, MD, FACC

When Mites Meet Their Match: Empowering Patients With Targeted Treatment for 𝘋𝘦𝘮𝘰𝘥𝘦𝘹 Blepharitis

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Mile Brujic, OD, FAAO; Pierce Kenworthy, OD, FAAO; Blair Lonsberry, MS, OD, MEd, FAAO

Burst CME™: Burden of Sickle Cell Disease

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Matthew Heeney, MD; Biree Andemariam, MD

Burst CME™: Burden of Sickle Cell Disease

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Matthew Heeney, MD; Biree Andemariam, MD

Burst CME™: Recognizing Lupus Nephritis—From Timely Diagnosis to Appreciating the Underlying Mechanisms of Disease

Burst CME™: Recognizing Lupus Nephritis—From Timely Diagnosis to Appreciating the Underlying Mechanisms of Disease

Michelle Petri, MD, MPH; Shivani Garg, MD, PhD

Burst CME™: Recognizing Lupus Nephritis—From Timely Diagnosis to Appreciating the Underlying Mechanisms of Disease

Burst CME™: Recognizing Lupus Nephritis—From Timely Diagnosis to Appreciating the Underlying Mechanisms of Disease

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Bridging Regional Challenges in Retinal Disease Management: Applying Advanced Anti-VEGF Therapy in Community Practice - Florida

Bridging Regional Challenges in Retinal Disease Management: Applying Advanced Anti-VEGF Therapy in Community Practice - Florida

Carl J. Danzig, MD, FASRS

The Rise of Novel HER2-Targeting Therapies in GEA: Mechanisms and Clinical Data

The Rise of Novel HER2-Targeting Therapies in GEA: Mechanisms and Clinical Data

Rahul Gosain, MD, MBA; Rohit Gosain, MD

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