Opinion|Videos|March 24, 2025
Rapid Efficacy and Safety Considerations With the Use of JAK Inhibitors in Atopic Dermatitis Care
Panelists discuss how Janus kinase (JAK) inhibitors such as upadacitinib, abrocitinib, and baricitinib offer rapid, oral treatment for moderate to severe atopic dermatitis, differing from injectable biologics in administration, broader immunosuppression, and risk of adverse events like thromboembolism. They provide effective symptom control but require safety monitoring.
Advertisement
Episodes in this series
Video content above in prompted by the following:
- How have JAK inhibitors (upadacitinib, abrocitinib, baricitinib) changed the treatment of moderate to severe atopic dermatitis, and in what ways to they differ from traditional biologics in terms of administration, safety, and efficacy?
Advertisement
Related to this article
Experts outline when to stop cycling topical steroids in chronic hand eczema and where topical delgocitinib now fits.
Dupilumab cut new or worsening allergies by 34% vs placebo in a 12-trial atopic dermatitis meta-analysis, suggesting it may slow the atopic march.
Emma Guttman-Yassky, MD, discusses biomarker data showing rezpegaldesleukin's regulatory T-cell mechanism separates from placebo early.
Approval of obinutuzumab for adults with PMN follows MAJESTY, where 37% vs 6% achieved complete remission at week 104 vs tacrolimus.
A post hoc, unmatched comparison presented at ACAAI 2026 found similar 14-day improvements in urticaria activity with omalizumab vs remibrutinib.
Oral icotrokinra beat placebo and was noninferior to ustekinumab in moderate to severe plaque psoriasis in the phase 3 ICONIC-ASCEND trial.
HIBISCUS showed a 48.7% vs 7.2% hemoglobin response at week 24, with an FDA decision expected in 2027.
TRANSCEND-T2D-2 topline data show retatrutide lowered A1C more and produced over twice the weight loss of semaglutide 2 mg in type 2 diabetes.
Advertisement
Advertisement
Trending on HCPLive
1
Q&A: Mucus Plugging, Multimorbidity, and GOLD 2027, With Gerard Criner, MD
2
ABCs in Dermatology: Rethinking Corticosteroid Stewardship in Chronic Hand Eczema
3
Etavopivat Submitted to FDA After 27% VOC Reduction in Phase 3 SCD Trial
4
Omalizumab Biosimilar CT-P39: Quality of Life Gains Precede CSU Control
5