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This Year In Medicine 2025

Opinion|Videos|March 24, 2025

Rapid Efficacy and Safety Considerations With the Use of JAK Inhibitors in Atopic Dermatitis Care

Author(s)Brad P. Glick, DO, MPH, Zed Zha, MD, FAAFP, Charles Vega, MD, FAAFP

Panelists discuss how Janus kinase (JAK) inhibitors such as upadacitinib, abrocitinib, and baricitinib offer rapid, oral treatment for moderate to severe atopic dermatitis, differing from injectable biologics in administration, broader immunosuppression, and risk of adverse events like thromboembolism. They provide effective symptom control but require safety monitoring.

Episodes in this series

EP. 1 Frontline Management of Atopic Dermatitis in Adults

EP. 1 Frontline Management of Atopic Dermatitis in Adults

5 experts in this video

EP. 2 Considerations for Diagnosis of Atopic Dermatitis in Adults

5 experts in this video

EP. 3 A Primary Care Perspective on Diagnosing Atopic Dermatitis

5 experts in this video

EP. 4 Strategies for Determining Severity of Atopic Dermatitis

5 experts in this video

EP. 5 Collaboration Between Primary Care and Dermatology in Atopic Dermatitis Care

5 experts in this video

EP. 6 The Utility of Newer Topical Therapies for Atopic Dermatitis

5 experts in this video

EP. 7 The Impact of Biologics on a Changing Atopic Dermatitis Treatment Landscape

5 experts in this video

EP. 8 A Primary Care Perspective on Newer-Generation Systemic Therapies

5 experts in this video

EP. 9 Safety of Systemic Agents in Atopic Dermatitis Management

5 experts in this video

EP. 10 LIBERTY AD Open-Label Extension Analysis: Takeaways and Considerations

5 experts in this video

EP. 11 ECZTEND 2-Year Interim Findings: Takeaways and Considerations

5 experts in this video

EP. 12 Rapid Efficacy and Safety Considerations With the Use of JAK Inhibitors in Atopic Dermatitis Care

5 experts in this video

EP. 13 Safety Protocols With JAK Inhibitors

5 experts in this video

EP. 14 JADE COMPARE: Considerations for Comparisons Among Systemic Agents in Atopic Dermatitis

5 experts in this video

EP. 15 Evaluation of Long-Term Data With JAK Inhibitors

5 experts in this video

EP. 16 Clinical Considerations for Choosing a Systemic Agent for Patients With Atopic Dermatitis

5 experts in this video

EP. 17 Multispecialty Perspectives on Shared Decision-Making in Atopic Dermatitis Care

5 experts in this video

EP. 18 Future Directions in the Management Atopic Dermatitis in Adult Patients

Video content above in prompted by the following:

How have JAK inhibitors (upadacitinib, abrocitinib, baricitinib) changed the treatment of moderate to severe atopic dermatitis, and in what ways to they differ from traditional biologics in terms of administration, safety, and efficacy?

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