
Opinion|Videos|January 1, 2025
Patient Case No. 1
Key Takeaways
- Difficult-to-treat hypertension involves uncontrolled blood pressure despite using three or more antihypertensive medications, including a diuretic.
- It is distinct from resistant hypertension, which is more common and may not include a diuretic in treatment.
Panelists discuss how evaluating uncontrolled hypertension in patients with early kidney dysfunction requires a careful investigation of underlying causes, including medication adherence, lifestyle factors, and potential secondary hypertension.
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Episodes in this series

- Patient No. 1 has uncontrolled hypertension despite the use of 4 antihypertensive drugs. They have a slightly abnormal estimated glomerular filtration rate suggestive of early kidney involvement. Their creatinine level is elevated, indicating impaired renal function.
- How would you approach the cause of uncontrolled blood pressure in this patient?
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