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This Year In Medicine 2025

Opinion|Videos|December 18, 2024

Endothelin Pathway

Author(s)Manesh R. Patel, MD, Payal Kohli, MD, FACC, John M. Flack, MD, MPH, FASH

Key Takeaways

Difficult-to-treat hypertension involves uncontrolled blood pressure despite using three or more antihypertensive medications, including a diuretic.
It is distinct from resistant hypertension, which is more common and may not include a diuretic in treatment.
This condition affects a smaller subset of patients with high blood pressure and requires a comprehensive management approach.
Lifestyle modifications and evaluation for secondary causes are crucial for optimal management of difficult-to-treat hypertension.

SHOW MORE

Panelists discuss how the endothelin pathway critically regulates blood pressure and vascular health through the interplay between vasodilators and vasoconstrictors such as endothelin-1, representing a key mechanism in hypertension pathophysiology.

Episodes in this series

4 experts are featured in this series.

EP. 1 Unmet Needs in HTN: Patient Adherence, Comorbid Conditions, and Prevalence

4 experts are featured in this series.

EP. 2 Current Limitations With Traditional Antihypertensive Drugs

4 experts are featured in this series.

EP. 3 Drug Classes Available to Treat Patients With High Blood Pressure

4 experts are featured in this series.

EP. 4 Difficult-to-Treat Hypertension Treatment Strategies

4 experts are featured in this series.

EP. 5 Current Therapeutic Guidelines for Managing Resistant Hypertension

4 experts are featured in this series.

EP. 6 Endothelin Pathway

4 experts are featured in this series.

EP. 7 PRECISION trial

4 experts are featured in this series.

EP. 8 Hypertension in Pregnancy and Women

4 experts are featured in this series.

EP. 9 Tips for Precise Readings

4 experts are featured in this series.

EP. 10 Patient Case No. 1

4 experts are featured in this series.

EP. 11 Patient Case No. 2

Video content above is prompted by the following:

There are numerous factors that contribute to the pathophysiology of hypertension. One is the endothelin pathway, which plays a crucial role in regulating vascular tone, blood pressure, and vascular remodeling via vasodilators (eg, nitric oxide) and vasoconstrictors (eg, endothelin-1).

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