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Spotlight -

This Year In Medicine 2025

Opinion|Videos|January 8, 2025

Patient Case No. 2

Author(s)Manesh R. Patel, MD, Payal Kohli, MD, FACC, John M. Flack, MD, MPH, FASH

Key Takeaways

Difficult-to-treat hypertension involves uncontrolled blood pressure despite using three or more antihypertensive medications, including a diuretic.
It is distinct from resistant hypertension, which is more common and may not include a diuretic in treatment.
This condition affects a smaller subset of patients with high blood pressure and requires a comprehensive management approach.
Lifestyle modifications and evaluation for secondary causes are crucial for optimal management of difficult-to-treat hypertension.

SHOW MORE

Panelists discuss how chronic kidney disease (CKD) and uncontrolled hypertension create a damaging cycle, in which hypertension accelerates kidney damage while declining kidney function makes blood pressure harder to control.

Episodes in this series

4 experts are featured in this series.

EP. 1 Unmet Needs in HTN: Patient Adherence, Comorbid Conditions, and Prevalence

4 experts are featured in this series.

EP. 2 Current Limitations With Traditional Antihypertensive Drugs

4 experts are featured in this series.

EP. 3 Drug Classes Available to Treat Patients With High Blood Pressure

4 experts are featured in this series.

EP. 4 Difficult-to-Treat Hypertension Treatment Strategies

4 experts are featured in this series.

EP. 5 Current Therapeutic Guidelines for Managing Resistant Hypertension

4 experts are featured in this series.

EP. 6 Endothelin Pathway

4 experts are featured in this series.

EP. 7 PRECISION trial

4 experts are featured in this series.

EP. 8 Hypertension in Pregnancy and Women

4 experts are featured in this series.

EP. 9 Tips for Precise Readings

4 experts are featured in this series.

EP. 10 Patient Case No. 1

4 experts are featured in this series.

EP. 11 Patient Case No. 2

Patient No. 2 has stage 3 CKD and uncontrolled hypertension. They have a moderate reduction in their estimated glomerular filtration rate, confirming stage 3 CKD. Their hypertension is likely contributing to CKD progression.

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