Victoria Johnson joined the MJH Life Sciences in 2020 and has written for NeurologyLive, CGTLive, and now HCPLive. You can reach her at vjohnson@mjhlifesciences.com
Tezepelumab Fails Study Endpoint of Reducing Moderate-to-Severe COPD Exacerbations
However, subgroup analyses may reveal a more pronounced effect in people with severe COPD.
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Cost-Related Non-Adherence Declines for Asthma, More Action Needed
CRN declined from 23.2% to 13.1% between 2011 and 2022 but still affects around 2.5 million adults in the US.
People With Fibromyalgia May Have Impaired Mitochondrial Function
The lower BHI observed was likely associated with effects on the musculoskeletal system and not the central nervous system.
No Risk of Neuropsychiatric AEs With Montelukast Over LABA Agents for Asthma, Allergic Rhinitis
New findings cast doubt on required black box warnings for montelukast (brand name Singulair).
Non-Urgent ED Utilization High For People With PsA, AS in Rural Areas
Infection and injury were the most common responsible diagnoses for patinets with both PsA or AS.
Air Pollution, Climate Change Exacerbate COPD, Asthma
Meteorological conditions’ effect on exacerbations were likely mediated by particulate matter.
JAKi Treatment for Psoriatic Arthritis Not Associated With Increased CVD, VTE, Cancer Risk
Cancer risk was examined for breast, colorectal, lung, and prostate cancer.
Pegloticase Does Not Increase Risk of CV/TE Events in People With Gout
A post-hoc analysis evaluated pooled data from 4 trials of pegloticase.
Research Confirms Cold Therapy Benefits During Gout Flares
Heat therapy often worsened symptoms in a randomized controlled trial.
Elevated Serum cAMP Findings May Allow Asthma Diagnosis by Blood Test
Current asthma diagnosis requires specialized breathing tests that can be challenging for young children.
Fertility Unaffected by Biologic Therapy in Women With RA, PsA
Virtual Reality Exercise Game Feasible for Patients With Fibromyalgia
A VR exergame may facilitate patients’ physical activity while promoting relaxation and positive mental states.
Fall Prevention Strategies Needed for Adults With COPD
Within 2 years of death, fall-risk increasing drug burden was associated with greater odds of an injurious fall.
USPSTF Finalizes 2024 Osteoporosis Screening Recommendations
Recommendations have been largely preserved since 2018 and the USPSTF acknowledged the need for more research and better risk assessment tools.
Gout Flare State Definitions Help Describe Disease Burden
However, gout flare states of patient acceptable symptom state, low disease activity, or not achieving either were not associated with EQ-5D-3L or HAQ.
High Risk of Severe Infections in Patients With Rheumatic Diseases After Kidney Transplant
Investigators found an incidence of 26.2 severe infections per 100 patient-years with 4 deaths in the study.
Meta-Analysis Confirms Efficacy of Small Molecules for Psoriatic Arthritis
Small molecule drugs may help fill gaps in treatment with biologic therapies.
Early Control of Rheumatoid Arthritis Improves Hemostatic Imbalance
Tocilizumab and other biological drugs were particularly efficacious in lowering overall hemostatic potential, mitigating blood clot risks.
DMARD-Free Remission Feasible for bDMARD-Naive Patients for RA
Around 37% of those had never used a bDMARD reached sustained DMARD-free remission at 5 years,
Caroline Piatek, MD: High HCRU, Patient Concerns Highlight Great Unmet Need in wAIHA
Piatek discussed findings from a healthcare resource utilization study and a sentiment analysis study presented at ASH 2024.
Biosimilars Month in Review: December 2024
The biosimilars month in review highlights a newly approved ustekinumab biosimilar and a look into the field in 2024.
Aflibercept Biosimilar Demonstrates Therapeutic Equivalence for DME
CT-P42 may help improve access to aflibercept in lower-income countries.
Cannabinoid-Based Formula Demonstrates Proof-of-Concept for Treating RA
Despite improvements in PROs and disease activity, no statistically significant changes have been seen on blood biomarker analysis.
Rheumatology Month in Review: December 2024
The rheumatology month in review emphasizes new research in PsA and on cardiovascular events in rheumatic disease.
Gabapentin Does Not Increase Risk of Falls in Older Adults with Fibromyalgia
An active comparator study found that incident use of gabapentin was associated with lower rates of falls than duloxetine and similar rates of severe falls.
Steven W. Pipe, MD: Supporting Gene Therapy Implementation for Hemophilia
Pipe discussed a symposium at ASH 2024 about practical implementation of gene therapy in the field.
Corinna L. Schultz, MD: Improving Sickle Cell Trait Documentation in Infancy
Schultz discussed the SCtalk trial and its findings at ASH 2024.
Adherence Low for ULT Dosing ACR Gout Guidelines
Less than half of rheumatologists self-reported adhering to febuxostat and allopurinol dosing recommendations.
Sibgha Zaheer, MD: Determining Washout Period With Fitusiran, Emicizumab Transition for Hemophilia
Zaheer discussed how this research may be used as a model to help study other therapy transitions as well.
Rheumatoid Arthritis Heart Failure Risk Driven by Increased HFpEF Risk
Other recent research presented at ACR 2024 found increased CVD risk with glucocorticosteroid use.