C Difficile Infection

New evidence from a cumulative RCT analysis suggests irritable bowel syndrome patients do not definitively benefit from FMT treatment.

Study presented at DDW 2019 found that transplantation of gut microbes from lean donor could aid weight loss in obese, metabolically healthy recipients.

The new guideline centers on the overall diagnosis, management, and clinical treatment of the chronic inflammatory disease.

For 2 years after C difficile infection, patients under 65 years were at greater risk for gastrointestinal diagnoses compared to uninfected patients.

Investigators hope their findings will alleviate clinicians’ concerns about choosing between fidaxomicin and oral vancomycin for treatment.

Currently in phase 1 testing, ACX-362E is being developed as a narrow spectrum antibiotic for the treatment of Clostridium difficile infection.

Success with metronidazole was more likely in patients 65 years and under but was about the same as with vancomycin in those patients.

At 10%, recurrence was lower in this analysis compared to other pediatric studies.

Despite the cost, ultraviolet disinfection helped reduce infection rates in a recent study.

The antibacterial therapy has been indicated for forms of the disease driven by E. coli.

How many days between hospital admission and surgery could play a significant role, investigators noted.

A launderable mattress barrier has shown to decrease hospital-onset Clostridium difficile infections.

Glenn Tillotson, PhD, highlights possible treatment options besides antibiotics that may be worth evaluating for the infectious disease.

Dale Gerding, MD, highlights newest and most promising treatment approaches and preventions for C difficile.

Nicola Petrosillo, MD, discusses current controversies in C difficile prevention and treatment.

For patients with inflammatory bowel disease (IBD) and C difficile, immunosuppressive therapy escalation for IBD, after treatment for the infection, was not associated with adverse outcomes.

These non-critical items are often used on multiple patients, and a lack of knowledge about proper cleaning and disinfection could contribute to the spread of C difficile.

Patients who acquired C difficile infection while in the hospital were more than twice as likely to be discharged somewhere other than home, such as to a nursing home or long-term care facility.

Female sex, previous gastrointestinal, and non-gastrointestinal comorbidities are associated with C difficile infection in women with UTIs, study finds.

Placing patients with community-acquired C difficile infection in single-occupancy hospital rooms may not be necessary to prevent the spread of C difficile, suggests a recent study.

A new study is the first to identify eosinophil counts as a predictor of outcomes in human patients.

Investigators found 16S rRNA gene qPCR to be more sensitive than culture for detecting C difficile on environmental surfaces.

Implementation of antimicrobial stewardship programs in outpatient dialysis centers reduce infections caused by multidrug-resistant organisms, including Clostridium difficile.

A new survey found that Clostridium difficile infections have a substantial impact on the health-related quality of work, work life, and physical activity of those who are infected.

Ridinilazole caused less microbiota disruption, and investigators believe it may be superior to vancomycin for preventing Clostridium difficile infection recurrence.