On the HCPLive Sickle Cell condition center page, resources on the topics of medical news and expert insight into sickle cell disease can be found. Content includes articles, interviews, videos, podcasts, and breaking news on sickle cell research, treatment, and drug development.
May 14th 2024
Age and sickle cell disease genotype predicted individuals with sickle cell retinopathy at risk for proliferative disease.
NIH Launches Initiative to Accelerate Curative Genetic Therapies for Sickle Cell Disease
The National Institutes of Health has launched the Cure Sickle Cell Initiative to accelerate the pace at which genetic-based curative therapies are developed for sickle cell disease.
Cancer & Sickle Cell Disease Treatments Can Increase Risk of Infertility
Investigators find boys treated with alkylating agents or with hydroxyurea for sickle cell disease resulted in a significant reduction in spermatogonial cell counts, suggesting that these agents can affect fertility.
L-glutamine Oral Powder Significantly Reduces Acute Complications of Sickle Cell Disease
The New England Journal of Medicine has published the 48-week phase 3 clinical trial results that supported the FDA approval of L-glutamine oral powder for the reduction of acute complications of sickle cell disease in adult and pediatric patients.
Update on Phase 2a Voxelotor Data in Adolescents with Sickle Cell Disease Released
Updated 24-week data was released from patients treated with the 900 mg dose of voxelotor in the ongoing HOPE-KIDS 1 Study, a phase 2a open-label study in adolescents ages 6 to 17 years with sickle cell disease (SCD).
FDA Accepts IND Application for BIVV003, a Gene Therapy for Sickle Cell Disease
The US Food and Drug Administration (FDA) has accepted the Bioverativ's Investigational New Drug (IND) application for BIVV003, a gene-edited cell therapy candidate for the treatment of people with sickle cell disease.
Q&A with Barbara Cappelli: HLA- Sibling Transplants Works in Sickle Cell Disease
Barbara Cappelli, MD, Eurocord International Registry, Paris, France, shared an overview from her team's study that found further evidence that for patients with severe sickle cell disease who have an HLA-identical sibling available as a donor, HSCT can be safe and effective.
Equations with Both Serum Cystatin C and Creatinine Inaccurately Estimate Glomerular Filtration Rate
Sickle cell disease, as debilitating as it is, is associated with the progressive complication of renal damage – beginning with hyerfiltration in childhood to glomerular filtration rate (GFR) decline and chronic renal failure in approximately 12 % of HbSS sickle cell adults.
Opioid Prescription Practices May Influence Pain Episodes in Pediatric Sickle Cell Disease
December 2nd 2015Thirty-day emergency room readmissions due to acute pain is not uncommon in children with sickle cell disease, and researchers suspect that opioid prescription practices has something to do with it.