
IgG4-related disease can involve almost any organ and often begins without symptoms. The panel defines the condition, outlines who it affects, and describes the many ways it presents.
International experts in gastroenterology, hepatology, rheumatology, and immunology discuss how IgG4-related disease presents across organ systems, how to distinguish it from its mimics, and why B cells drive its biology. They review glucocorticoid-sparing strategies, phase 3 data on B-cell depletion and inhibition, emerging therapies, long-term monitoring, and new international guidelines.

IgG4-related disease can involve almost any organ and often begins without symptoms. The panel defines the condition, outlines who it affects, and describes the many ways it presents.

Malignancy, vasculitis, and sarcoidosis all overlap with IgG4-related disease. The panel reviews key mimics by organ and contrasts manifestations needing immediate treatment with those suited to active surveillance.