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Spotlight -

This Year In Medicine 2025

Opinion|Videos|April 9, 2025

Advances in the Understanding of Hypercortisolism

Author(s)Pamela Kushner, MD, FAAFP , John Anderson, MD, John Buse, MD, PhD

Experts discuss the long-term health impacts of hypercortisolism, including unresolved comorbidities and increased mortality risk, the consequences of delayed diagnosis, and how the understanding of its clinical presentation has evolved.

Episodes in this series

EP. 1 Practical Strategies for Identifying and Screening for Hypercortisolism

EP. 1 Practical Strategies for Identifying and Screening for Hypercortisolism

EP. 2 Defining Hypercortisolism and Its Impact on Physical and Mental Health

EP. 2 Defining Hypercortisolism and Its Impact on Physical and Mental Health

EP. 3 Advances in the Understanding of Hypercortisolism

EP. 3 Advances in the Understanding of Hypercortisolism

EP. 4 Key Learnings From the CATALYST Study on Hypercortisolism Prevalence

EP. 4 Key Learnings From the CATALYST Study on Hypercortisolism Prevalence

EP. 5 Overcoming Inertia in Hypercortisolism Identification

EP. 5 Overcoming Inertia in Hypercortisolism Identification

EP. 6 Importance of Primary Care in Identification and Screening for Hypercortisolism

EP. 6 Importance of Primary Care in Identification and Screening for Hypercortisolism

EP. 7 Who to Screen for Hypercortisolism

EP. 7 Who to Screen for Hypercortisolism

EP. 8 Dexamethasone Suppression to Identify Hypercortisolism

EP. 8 Dexamethasone Suppression to Identify Hypercortisolism

EP. 9 Effect of Hypercortisolism on Cardiovascular and Diabetes Care

EP. 9 Effect of Hypercortisolism on Cardiovascular and Diabetes Care

EP. 10 Importance of Multispecialty Communication in Hypercortisolism Management and Referrals

EP. 10 Importance of Multispecialty Communication in Hypercortisolism Management and Referrals

EP. 11 Addressing Potential Barriers to Implementing Hypercortisolism Screening in Practice

EP. 11 Addressing Potential Barriers to Implementing Hypercortisolism Screening in Practice

Video content above is prompted by the following:How can hypercortisolism affect a patient’s long-term health and quality of life?

Long-term risks remain for patients even if hypercortisolism remission is achieved, including incomplete resolution of comorbidities, reduced quality of life, and increased mortality risk.
What are some of the consequences of a delayed or missed hypercortisolism diagnosis?
Increased risk of cardiometabolic abnormalities, osteoporosis, and psychiatric disorders
Increase in mortality rate compared with the general population
How has our understanding of the clinical presentation of hypercortisolism evolved?
Overt, hallmark symptoms and features vs nonspecific features and symptoms overlapping with chronic disease

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Advances in™: Lipoprotein(a) as a Target for ASCVD Risk Reduction – Updates for Clinical Practice

Advances in™: Lipoprotein(a) as a Target for ASCVD Risk Reduction – Updates for Clinical Practice

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When Mites Meet Their Match: Empowering Patients With Targeted Treatment for 𝘋𝘦𝘮𝘰𝘥𝘦𝘹 Blepharitis

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Burst CME™: Burden of Sickle Cell Disease

Burst CME™: Burden of Sickle Cell Disease

Matthew Heeney, MD; Biree Andemariam, MD

Burst CME™: Burden of Sickle Cell Disease

Burst CME™: Burden of Sickle Cell Disease

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Burst CME™: Recognizing Lupus Nephritis—From Timely Diagnosis to Appreciating the Underlying Mechanisms of Disease

Burst CME™: Recognizing Lupus Nephritis—From Timely Diagnosis to Appreciating the Underlying Mechanisms of Disease

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Burst CME™: Recognizing Lupus Nephritis—From Timely Diagnosis to Appreciating the Underlying Mechanisms of Disease

Burst CME™: Recognizing Lupus Nephritis—From Timely Diagnosis to Appreciating the Underlying Mechanisms of Disease

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Bridging Regional Challenges in Retinal Disease Management: Applying Advanced Anti-VEGF Therapy in Community Practice - Florida

Bridging Regional Challenges in Retinal Disease Management: Applying Advanced Anti-VEGF Therapy in Community Practice - Florida

Carl J. Danzig, MD, FASRS

The Rise of Novel HER2-Targeting Therapies in GEA: Mechanisms and Clinical Data

The Rise of Novel HER2-Targeting Therapies in GEA: Mechanisms and Clinical Data

Rahul Gosain, MD, MBA; Rohit Gosain, MD

From Suspicion to Stabilization: Early Recognition and Treatment of Paraneoplastic LEMS

From Suspicion to Stabilization: Early Recognition and Treatment of Paraneoplastic LEMS

Charu Aggarwal, MD, MPH, FASCO; Erminia Massarelli, MD, PhD, MS; Ruham Nasany, MD

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