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This Year In Medicine 2025

Opinion|Videos|April 9, 2025

Defining Hypercortisolism and Its Impact on Physical and Mental Health

Author(s)Pamela Kushner, MD, FAAFP , John Anderson, MD, John Buse, MD, PhD

Experts discuss the physical impact of hypercortisolism on a patient, how the condition affects overall health, and the long-term risks that remain even after remission, including incomplete resolution of comorbidities, reduced quality of life, and increased mortality risk.

Episodes in this series

EP. 1 Practical Strategies for Identifying and Screening for Hypercortisolism

EP. 1 Practical Strategies for Identifying and Screening for Hypercortisolism

EP. 2 Defining Hypercortisolism and Its Impact on Physical and Mental Health

EP. 2 Defining Hypercortisolism and Its Impact on Physical and Mental Health

EP. 3 Advances in the Understanding of Hypercortisolism

EP. 3 Advances in the Understanding of Hypercortisolism

EP. 4 Key Learnings From the CATALYST Study on Hypercortisolism Prevalence

EP. 4 Key Learnings From the CATALYST Study on Hypercortisolism Prevalence

EP. 5 Overcoming Inertia in Hypercortisolism Identification

EP. 5 Overcoming Inertia in Hypercortisolism Identification

EP. 6 Importance of Primary Care in Identification and Screening for Hypercortisolism

EP. 6 Importance of Primary Care in Identification and Screening for Hypercortisolism

EP. 7 Who to Screen for Hypercortisolism

EP. 7 Who to Screen for Hypercortisolism

EP. 8 Dexamethasone Suppression to Identify Hypercortisolism

EP. 8 Dexamethasone Suppression to Identify Hypercortisolism

EP. 9 Effect of Hypercortisolism on Cardiovascular and Diabetes Care

EP. 9 Effect of Hypercortisolism on Cardiovascular and Diabetes Care

EP. 10 Importance of Multispecialty Communication in Hypercortisolism Management and Referrals

EP. 10 Importance of Multispecialty Communication in Hypercortisolism Management and Referrals

EP. 11 Addressing Potential Barriers to Implementing Hypercortisolism Screening in Practice

EP. 11 Addressing Potential Barriers to Implementing Hypercortisolism Screening in Practice

Video content above is prompted by the following:

Can you describe the physical impact of hypercortisolism on a patient? How does this condition affect patients’ overall health?
How can hypercortisolism affect a patient’s long-term health and quality of life?
Long-term risks remain for patients even if hypercortisolism remission is achieved, including incomplete resolution of comorbidities, reduced quality of life, and increased mortality risk.

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