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This Year In Medicine 2025

Opinion|Videos|February 20, 2025

BTK Inhibition as a Strategy for CSU Treatment

Author(s)Giselle Mosnaim, MD, MS , Shyam Joshi, MD , Mark Lebwohl, MD

Panelists discuss how Bruton tyrosine kinase (BTK) inhibition could effectively treat both autoallergic and autoimmune chronic spontaneous urticaria (CSU).

Episodes in this series

EP. 1 Chronic Spontaneous Urticaria and Bruton Tyrosine Kinase: A Multispecialty Expert Discussion

EP. 1 Chronic Spontaneous Urticaria and Bruton Tyrosine Kinase: A Multispecialty Expert Discussion

EP. 2 Pathophysiology of Chronic Spontaneous Urticaria

EP. 3 Current CSU Treatment Approach and the Role of Bruton Tyrosine Kinase

EP. 3 Current CSU Treatment Approach and the Role of Bruton Tyrosine Kinase

EP. 4 BTK Inhibition as a Strategy for CSU Treatment

EP. 4 BTK Inhibition as a Strategy for CSU Treatment

EP. 5 How BTK Inhibitors Differ From Current CSU Treatment Approaches

EP. 5 How BTK Inhibitors Differ From Current CSU Treatment Approaches

EP. 6 Overview of BTK Inhibitors in Development for CSU Treatment

EP. 6 Overview of BTK Inhibitors in Development for CSU Treatment

EP. 7 Differentiating BTK Inhibition From Genetic BTK Deficiency

EP. 7 Differentiating BTK Inhibition From Genetic BTK Deficiency

EP. 8 Overview of Remibrutinib Phase 3 Clinical Trials in CSU

EP. 8 Overview of Remibrutinib Phase 3 Clinical Trials in CSU

EP. 9 CSU Burden of Disease and Quality of Life

EP. 9 CSU Burden of Disease and Quality of Life

EP. 10 Early Clinical Trial Data for Rilzabrutinib in CSU and Future Study Directions

EP. 10 Early Clinical Trial Data for Rilzabrutinib in CSU and Future Study Directions

EP. 11 How BTK Inhibitors Might Address Unmet Treatment Needs in CSU

EP. 11 How BTK Inhibitors Might Address Unmet Treatment Needs in CSU

EP. 12 Evolving Paradigm for CSU Treatment

EP. 12 Evolving Paradigm for CSU Treatment

EP. 13 Additional Data Needs for BTK Inhibitors in CSU

EP. 13 Additional Data Needs for BTK Inhibitors in CSU

EP. 14 Key Takeaways and Considerations for the Use of BTK Inhibitors in CSU Treatment

EP. 14 Key Takeaways and Considerations for the Use of BTK Inhibitors in CSU Treatment

Video content above is prompted by the following:

• How would targeting BTK through inhibition be a strategy in the treatment of both IgE (autoallergic) and IgG (autoimmune) CSU?
• Covalent binding enables high and sustained occupancy of BTK without the need for sustained systemic exposure.

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