Opinion|Videos|February 13, 2025
Pathophysiology of Chronic Spontaneous Urticaria
Panelists discuss how chronic spontaneous urticaria develops through 2 distinct pathways: autoallergic CSU involving IgE-mediated mast cell activation (type I hypersensitivity) and autoimmune CSU where IgG autoantibodies target FcεRI receptors or IgE itself (type IIb hypersensitivity), both ultimately leading to mast cell degranulation and wheal formation.
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Video content above is prompted by the following:
- Describe the pathogenesis of chronic spontaneous urticaria (CSU), including the IgE (autoallergic; type I) and IgG (autoimmune; type IIb) CSU subtypes.
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