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This Year In Medicine 2025

Opinion|Videos|February 13, 2025

Pathophysiology of Chronic Spontaneous Urticaria

Author(s)Giselle Mosnaim, MD, MS , Shyam Joshi, MD , Mark Lebwohl, MD

Panelists discuss how chronic spontaneous urticaria develops through 2 distinct pathways: autoallergic CSU involving IgE-mediated mast cell activation (type I hypersensitivity) and autoimmune CSU where IgG autoantibodies target FcεRI receptors or IgE itself (type IIb hypersensitivity), both ultimately leading to mast cell degranulation and wheal formation.

Episodes in this series

EP. 1 Chronic Spontaneous Urticaria and Bruton Tyrosine Kinase: A Multispecialty Expert Discussion

EP. 1 Chronic Spontaneous Urticaria and Bruton Tyrosine Kinase: A Multispecialty Expert Discussion

EP. 2 Pathophysiology of Chronic Spontaneous Urticaria

EP. 3 Current CSU Treatment Approach and the Role of Bruton Tyrosine Kinase

EP. 3 Current CSU Treatment Approach and the Role of Bruton Tyrosine Kinase

EP. 4 BTK Inhibition as a Strategy for CSU Treatment

EP. 4 BTK Inhibition as a Strategy for CSU Treatment

EP. 5 How BTK Inhibitors Differ From Current CSU Treatment Approaches

EP. 5 How BTK Inhibitors Differ From Current CSU Treatment Approaches

EP. 6 Overview of BTK Inhibitors in Development for CSU Treatment

EP. 6 Overview of BTK Inhibitors in Development for CSU Treatment

EP. 7 Differentiating BTK Inhibition From Genetic BTK Deficiency

EP. 7 Differentiating BTK Inhibition From Genetic BTK Deficiency

EP. 8 Overview of Remibrutinib Phase 3 Clinical Trials in CSU

EP. 8 Overview of Remibrutinib Phase 3 Clinical Trials in CSU

EP. 9 CSU Burden of Disease and Quality of Life

EP. 9 CSU Burden of Disease and Quality of Life

EP. 10 Early Clinical Trial Data for Rilzabrutinib in CSU and Future Study Directions

EP. 10 Early Clinical Trial Data for Rilzabrutinib in CSU and Future Study Directions

EP. 11 How BTK Inhibitors Might Address Unmet Treatment Needs in CSU

EP. 11 How BTK Inhibitors Might Address Unmet Treatment Needs in CSU

EP. 12 Evolving Paradigm for CSU Treatment

EP. 12 Evolving Paradigm for CSU Treatment

EP. 13 Additional Data Needs for BTK Inhibitors in CSU

EP. 13 Additional Data Needs for BTK Inhibitors in CSU

EP. 14 Key Takeaways and Considerations for the Use of BTK Inhibitors in CSU Treatment

EP. 14 Key Takeaways and Considerations for the Use of BTK Inhibitors in CSU Treatment

Video content above is prompted by the following:

Describe the pathogenesis of chronic spontaneous urticaria (CSU), including the IgE (autoallergic; type I) and IgG (autoimmune; type IIb) CSU subtypes.

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