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Spotlight -

This Year In Medicine 2025

Opinion|Videos|March 27, 2025

Key Takeaways and Considerations for the Use of BTK Inhibitors in CSU Treatment

Author(s)Giselle Mosnaim, MD, MS , Shyam Joshi, MD , Mark Lebwohl, MD

Panelists discuss how Bruton tyrosine kinase (BTK) inhibitors represent a promising new therapeutic class for chronic spontaneous urticaria (CSU) by offering rapid symptom control through targeted inhibition of both mast cell and B cell pathways, with newer agents like remibrutinib showing high selectivity, favorable safety, and robust efficacy in clinical trials that could position them as an important oral therapy option between antihistamines and biologics.

Episodes in this series

EP. 1 Chronic Spontaneous Urticaria and Bruton Tyrosine Kinase: A Multispecialty Expert Discussion

EP. 1 Chronic Spontaneous Urticaria and Bruton Tyrosine Kinase: A Multispecialty Expert Discussion

EP. 2 Pathophysiology of Chronic Spontaneous Urticaria

EP. 3 Current CSU Treatment Approach and the Role of Bruton Tyrosine Kinase

EP. 3 Current CSU Treatment Approach and the Role of Bruton Tyrosine Kinase

EP. 4 BTK Inhibition as a Strategy for CSU Treatment

EP. 4 BTK Inhibition as a Strategy for CSU Treatment

EP. 5 How BTK Inhibitors Differ From Current CSU Treatment Approaches

EP. 5 How BTK Inhibitors Differ From Current CSU Treatment Approaches

EP. 6 Overview of BTK Inhibitors in Development for CSU Treatment

EP. 6 Overview of BTK Inhibitors in Development for CSU Treatment

EP. 7 Differentiating BTK Inhibition From Genetic BTK Deficiency

EP. 7 Differentiating BTK Inhibition From Genetic BTK Deficiency

EP. 8 Overview of Remibrutinib Phase 3 Clinical Trials in CSU

EP. 8 Overview of Remibrutinib Phase 3 Clinical Trials in CSU

EP. 9 CSU Burden of Disease and Quality of Life

EP. 9 CSU Burden of Disease and Quality of Life

EP. 10 Early Clinical Trial Data for Rilzabrutinib in CSU and Future Study Directions

EP. 10 Early Clinical Trial Data for Rilzabrutinib in CSU and Future Study Directions

EP. 11 How BTK Inhibitors Might Address Unmet Treatment Needs in CSU

EP. 11 How BTK Inhibitors Might Address Unmet Treatment Needs in CSU

EP. 12 Evolving Paradigm for CSU Treatment

EP. 12 Evolving Paradigm for CSU Treatment

EP. 13 Additional Data Needs for BTK Inhibitors in CSU

EP. 13 Additional Data Needs for BTK Inhibitors in CSU

EP. 14 Key Takeaways and Considerations for the Use of BTK Inhibitors in CSU Treatment

EP. 14 Key Takeaways and Considerations for the Use of BTK Inhibitors in CSU Treatment

Video content above is prompted by the following:

What are some key takeaways on the potential use of BTK inhibitors in the treatment of CSU that you’d like to share with clinicians managing this condition?

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Q&A: How Is Risankizumab’s FDA Approval Changing the Psoriatic Disease Landscape?

New Nonsteroidal Options Are Reshaping Pediatric Atopic Dermatitis Care

FDA Approves Ryaltris for Children Aged 6 to 11 With Seasonal Allergic Rhinitis