Differential Diagnoses of IgAN

Author(s):

Jonathan Barratt, PhD, FRCP,Anuja Java, MD

Key Takeaways

IgA nephropathy diagnosis involves clinical evaluation, laboratory tests, and renal biopsy to differentiate from similar glomerular diseases.
Renal biopsy with immunofluorescence microscopy is crucial, revealing mesangial IgA deposits specific to IgAN.
Lupus nephritis shows full-house immunofluorescence staining, while membranous nephropathy has subepithelial immune deposits.
Accurate differentiation is essential for appropriate disease management and treatment strategies.

Panelists discuss how clinicians can differentiate IgA nephropathy from other glomerular diseases, such as lupus nephritis and membranous nephropathy, that may present with similar clinical features.

Differential Diagnoses of IgAN

Key Takeaways

EP: 1.Overview of IgAN and Its Common Symptoms

EP: 2.IgAN Progression

EP: 3.IgAN vs Other Glomerular Diseases

EP: 4.Biomarkers for IgAN

EP: 5.Genetic Screening for IgAN

EP: 6.Impact of IgAN on Quality of Life

EP: 7.Misdiagnosis and Barriers to Early Detection of IgAN

EP: 8.Differential Diagnoses of IgAN

EP: 9.Significance of Proteinuria for Potential IgAN

EP: 10.Proteinuria Variability and IgAN Diagnosis

EP: 11.Biomarkers and Improving IgAN Diagnostic Accuracy

EP: 12.Primary Treatment Goals for Patients With IgAN

EP: 13.Proteinuria Reduction in Long-Term Kidney Damage Prevention

EP: 14.Symptoms Management and Targeting the Root Cause of IgAN

EP: 15.Unmet Needs in Current IgAN Treatment

EP: 16.Prospective Improvements of Existing IgAN Therapies

EP: 17.Safety of IgAN Treatments

EP: 18.The Promise of Emerging IgAN Therapies

EP: 19.Emerging Therapies: a look at the current data: ALIGN

EP: 20.Emerging Therapies: a look at the current data: APPLAUSE

EP: 21.Emerging Therapies: a look at the current data: PROTECT study

EP: 22.Emerging Therapies: a look at the current data: NefIgArd study