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Spotlight -

This Year In Medicine 2025

Opinion|Videos|November 25, 2024

Genetic Screening for IgAN

Author(s)Jonathan Barratt, PhD, FRCP, Anuja Java, MD, Brendon Neuen, MBBS, PhD

Key Takeaways

Familial IgA nephropathy constitutes up to 15% of cases, prompting consideration of family member screening.
No consensus exists on routine screening, but monitoring first-degree relatives may be advisable.
Periodic assessments and genetic counseling could help evaluate risk and guide preventive measures.

SHOW MORE

Panelists discuss the importance of screening and monitoring family members of individuals with IgA nephropathy, noting that up to 15% of cases are familial and outlining recommendations for the frequency of such assessments.

Episodes in this series

EP. 1 Overview of IgAN and Its Common Symptoms

EP. 1 Overview of IgAN and Its Common Symptoms

EP. 2 IgAN Progression

EP. 2 IgAN Progression

EP. 3 IgAN vs Other Glomerular Diseases

EP. 3 IgAN vs Other Glomerular Diseases

EP. 4 Biomarkers for IgAN

EP. 4 Biomarkers for IgAN

EP. 5 Genetic Screening for IgAN

EP. 5 Genetic Screening for IgAN

EP. 6 Impact of IgAN on Quality of Life

EP. 6 Impact of IgAN on Quality of Life

EP. 7 Misdiagnosis and Barriers to Early Detection of IgAN

EP. 7 Misdiagnosis and Barriers to Early Detection of IgAN

EP. 8 Differential Diagnoses of IgAN

EP. 8 Differential Diagnoses of IgAN

EP. 9 Significance of Proteinuria for Potential IgAN

EP. 9 Significance of Proteinuria for Potential IgAN

EP. 10 Proteinuria Variability and IgAN Diagnosis

EP. 10 Proteinuria Variability and IgAN Diagnosis

EP. 11 Biomarkers and Improving IgAN Diagnostic Accuracy

EP. 11 Biomarkers and Improving IgAN Diagnostic Accuracy

EP. 12 Primary Treatment Goals for Patients With IgAN

EP. 12 Primary Treatment Goals for Patients With IgAN

EP. 13 Proteinuria Reduction in Long-Term Kidney Damage Prevention

EP. 13 Proteinuria Reduction in Long-Term Kidney Damage Prevention

EP. 14 Symptoms Management and Targeting the Root Cause of IgAN

EP. 14 Symptoms Management and Targeting the Root Cause of IgAN

EP. 15 Unmet Needs in Current IgAN Treatment

EP. 15 Unmet Needs in Current IgAN Treatment

EP. 16 Prospective Improvements of Existing IgAN Therapies

EP. 16 Prospective Improvements of Existing IgAN Therapies

EP. 17 Safety of IgAN Treatments

EP. 17 Safety of IgAN Treatments

EP. 18 The Promise of Emerging IgAN Therapies

EP. 18 The Promise of Emerging IgAN Therapies

EP. 19 Emerging Therapies: a look at the current data: ALIGN

EP. 19 Emerging Therapies: a look at the current data: ALIGN

EP. 20 Emerging Therapies: a look at the current data: APPLAUSE

EP. 20 Emerging Therapies: a look at the current data: APPLAUSE

EP. 21 Emerging Therapies: a look at the current data: PROTECT study

EP. 21 Emerging Therapies: a look at the current data: PROTECT study

EP. 22 Emerging Therapies: a look at the current data: NefIgArd study

EP. 22 Emerging Therapies: a look at the current data: NefIgArd study

EP. 23 Implementing New IgAN Therapies Into Clinical Practice

EP. 23 Implementing New IgAN Therapies Into Clinical Practice

EP. 24 Shared Decision-Making for IgAN Treatment

EP. 24 Shared Decision-Making for IgAN Treatment

EP. 25 Summary and Closing Remarks

EP. 25 Summary and Closing Remarks

Up to 15% of IgA nephropathy (IgAN) cases are considered familial, should. Should family members of individuals with IgAN be screened or monitored for signs of the disease? If yes, how often?

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