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Spotlight -

This Year In Medicine 2025

Opinion|Videos|January 13, 2025

Emerging Therapies: a look at the current data: APPLAUSE

Author(s)Jonathan Barratt, PhD, FRCP, Anuja Java, MD, Brendon Neuen, MBBS, PhD

Key Takeaways

Biomarkers, including genetic mutations and protein expressions, are vital for predicting disease progression and treatment response.
Advanced diagnostic techniques are essential for identifying molecular and cellular indicators that inform patient prognosis.
Clinical indicators like tumor size, stage, and overall health status are crucial in assessing disease outcomes.
Personalized medicine utilizes biomarkers to customize treatment plans, improving therapeutic efficacy and patient survival.

SHOW MORE

Panelists discuss how the ALIGN trial data inform the development and potential impact of emerging therapies for IgA nephropathy, particularly focusing on their efficacy in reducing proteinuria and addressing disease pathology.

Episodes in this series

EP. 1 Overview of IgAN and Its Common Symptoms

EP. 1 Overview of IgAN and Its Common Symptoms

EP. 2 IgAN Progression

EP. 2 IgAN Progression

EP. 3 IgAN vs Other Glomerular Diseases

EP. 3 IgAN vs Other Glomerular Diseases

EP. 4 Biomarkers for IgAN

EP. 4 Biomarkers for IgAN

EP. 5 Genetic Screening for IgAN

EP. 5 Genetic Screening for IgAN

EP. 6 Impact of IgAN on Quality of Life

EP. 6 Impact of IgAN on Quality of Life

EP. 7 Misdiagnosis and Barriers to Early Detection of IgAN

EP. 7 Misdiagnosis and Barriers to Early Detection of IgAN

EP. 8 Differential Diagnoses of IgAN

EP. 8 Differential Diagnoses of IgAN

EP. 9 Significance of Proteinuria for Potential IgAN

EP. 9 Significance of Proteinuria for Potential IgAN

EP. 10 Proteinuria Variability and IgAN Diagnosis

EP. 10 Proteinuria Variability and IgAN Diagnosis

EP. 11 Biomarkers and Improving IgAN Diagnostic Accuracy

EP. 11 Biomarkers and Improving IgAN Diagnostic Accuracy

EP. 12 Primary Treatment Goals for Patients With IgAN

EP. 12 Primary Treatment Goals for Patients With IgAN

EP. 13 Proteinuria Reduction in Long-Term Kidney Damage Prevention

EP. 13 Proteinuria Reduction in Long-Term Kidney Damage Prevention

EP. 14 Symptoms Management and Targeting the Root Cause of IgAN

EP. 14 Symptoms Management and Targeting the Root Cause of IgAN

EP. 15 Unmet Needs in Current IgAN Treatment

EP. 15 Unmet Needs in Current IgAN Treatment

EP. 16 Prospective Improvements of Existing IgAN Therapies

EP. 16 Prospective Improvements of Existing IgAN Therapies

EP. 17 Safety of IgAN Treatments

EP. 17 Safety of IgAN Treatments

EP. 18 The Promise of Emerging IgAN Therapies

EP. 18 The Promise of Emerging IgAN Therapies

EP. 19 Emerging Therapies: a look at the current data: ALIGN

EP. 19 Emerging Therapies: a look at the current data: ALIGN

EP. 20 Emerging Therapies: a look at the current data: APPLAUSE

EP. 20 Emerging Therapies: a look at the current data: APPLAUSE

EP. 21 Emerging Therapies: a look at the current data: PROTECT study

EP. 21 Emerging Therapies: a look at the current data: PROTECT study

EP. 22 Emerging Therapies: a look at the current data: NefIgArd study

EP. 22 Emerging Therapies: a look at the current data: NefIgArd study

EP. 23 Implementing New IgAN Therapies Into Clinical Practice

EP. 23 Implementing New IgAN Therapies Into Clinical Practice

EP. 24 Shared Decision-Making for IgAN Treatment

EP. 24 Shared Decision-Making for IgAN Treatment

EP. 25 Summary and Closing Remarks

EP. 25 Summary and Closing Remarks

In the phase 3 ALIGN trial (NCT04573478), atrasentan demonstrated a 36% relative reduction in proteinuria with placebo after 36 weeks of treatment. What other data points would be relevant for clinicians?

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Overcoming Barriers to Long-Acting Injectable Agents in Schizophrenia

Overcoming Barriers to Long-Acting Injectable Agents in Schizophrenia

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Community Collab: The Evolving Role of FcRN Inhibitors in the Management of Generalized Myasthenia Gravis (gMG)

Community Collab: The Evolving Role of FcRN Inhibitors in the Management of Generalized Myasthenia Gravis (gMG)

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The Presbyopia-Correcting and Toric IOL Playbook: Game-Changing Surgical Strategies to Enhance Patient Outcomes

The Presbyopia-Correcting and Toric IOL Playbook: Game-Changing Surgical Strategies to Enhance Patient Outcomes

Uday Devgan, MD, FACS, FRCS

Expert Illustrations & Commentary: Visualizing Novel Therapeutic Targets for Patients with Major Depressive Disorder

Expert Illustrations & Commentary: Visualizing Novel Therapeutic Targets for Patients with Major Depressive Disorder

Juan D. Oms, MD, FAPA; Linda Collado, MD, DABPN, FAPA; Ginger Shupe, MD

Cases and Conversations™: Navigating CKD and Heart Failure in T1D and T2D—Applying the Latest Guidelines and Evidence

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Advances in™: Lipoprotein(a) as a Target for ASCVD Risk Reduction – Updates for Clinical Practice

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Pam R. Taub, MD, FACC, FASPC; Payal Kohli, MD, FACC

When Mites Meet Their Match: Empowering Patients With Targeted Treatment for 𝘋𝘦𝘮𝘰𝘥𝘦𝘹 Blepharitis

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Mile Brujic, OD, FAAO; Pierce Kenworthy, OD, FAAO; Blair Lonsberry, MS, OD, MEd, FAAO

Burst CME™: Burden of Sickle Cell Disease

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Matthew Heeney, MD; Biree Andemariam, MD

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Burst CME™: Recognizing Lupus Nephritis—From Timely Diagnosis to Appreciating the Underlying Mechanisms of Disease

Burst CME™: Recognizing Lupus Nephritis—From Timely Diagnosis to Appreciating the Underlying Mechanisms of Disease

Michelle Petri, MD, MPH; Shivani Garg, MD, PhD

Burst CME™: Recognizing Lupus Nephritis—From Timely Diagnosis to Appreciating the Underlying Mechanisms of Disease

Burst CME™: Recognizing Lupus Nephritis—From Timely Diagnosis to Appreciating the Underlying Mechanisms of Disease

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Bridging Regional Challenges in Retinal Disease Management: Applying Advanced Anti-VEGF Therapy in Community Practice - Florida

Bridging Regional Challenges in Retinal Disease Management: Applying Advanced Anti-VEGF Therapy in Community Practice - Florida

Carl J. Danzig, MD, FASRS

The Rise of Novel HER2-Targeting Therapies in GEA: Mechanisms and Clinical Data

The Rise of Novel HER2-Targeting Therapies in GEA: Mechanisms and Clinical Data

Rahul Gosain, MD, MBA; Rohit Gosain, MD

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