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Spotlight -

This Year In Medicine 2025

Opinion|Videos|January 27, 2025

Implementing New IgAN Therapies Into Clinical Practice

Author(s)Jonathan Barratt, PhD, FRCP, Anuja Java, MD, Brendon Neuen, MBBS, PhD

Key Takeaways

Biomarkers, including genetic mutations and protein expressions, are vital for predicting disease progression and treatment response.
Advanced diagnostic techniques are essential for identifying molecular and cellular indicators that inform patient prognosis.
Clinical indicators like tumor size, stage, and overall health status are crucial in assessing disease outcomes.
Personalized medicine utilizes biomarkers to customize treatment plans, improving therapeutic efficacy and patient survival.

SHOW MORE

Panelists discuss how the approval of atrasentan is expected to significantly affect the treatment landscape for IgA nephropathy by offering a novel therapeutic option that targets both proteinuria reduction and the underlying immune dysregulation associated with the disease.

Episodes in this series

EP. 1 Overview of IgAN and Its Common Symptoms

EP. 1 Overview of IgAN and Its Common Symptoms

EP. 2 IgAN Progression

EP. 2 IgAN Progression

EP. 3 IgAN vs Other Glomerular Diseases

EP. 3 IgAN vs Other Glomerular Diseases

EP. 4 Biomarkers for IgAN

EP. 4 Biomarkers for IgAN

EP. 5 Genetic Screening for IgAN

EP. 5 Genetic Screening for IgAN

EP. 6 Impact of IgAN on Quality of Life

EP. 6 Impact of IgAN on Quality of Life

EP. 7 Misdiagnosis and Barriers to Early Detection of IgAN

EP. 7 Misdiagnosis and Barriers to Early Detection of IgAN

EP. 8 Differential Diagnoses of IgAN

EP. 8 Differential Diagnoses of IgAN

EP. 9 Significance of Proteinuria for Potential IgAN

EP. 9 Significance of Proteinuria for Potential IgAN

EP. 10 Proteinuria Variability and IgAN Diagnosis

EP. 10 Proteinuria Variability and IgAN Diagnosis

EP. 11 Biomarkers and Improving IgAN Diagnostic Accuracy

EP. 11 Biomarkers and Improving IgAN Diagnostic Accuracy

EP. 12 Primary Treatment Goals for Patients With IgAN

EP. 12 Primary Treatment Goals for Patients With IgAN

EP. 13 Proteinuria Reduction in Long-Term Kidney Damage Prevention

EP. 13 Proteinuria Reduction in Long-Term Kidney Damage Prevention

EP. 14 Symptoms Management and Targeting the Root Cause of IgAN

EP. 14 Symptoms Management and Targeting the Root Cause of IgAN

EP. 15 Unmet Needs in Current IgAN Treatment

EP. 15 Unmet Needs in Current IgAN Treatment

EP. 16 Prospective Improvements of Existing IgAN Therapies

EP. 16 Prospective Improvements of Existing IgAN Therapies

EP. 17 Safety of IgAN Treatments

EP. 17 Safety of IgAN Treatments

EP. 18 The Promise of Emerging IgAN Therapies

EP. 18 The Promise of Emerging IgAN Therapies

EP. 19 Emerging Therapies: a look at the current data: ALIGN

EP. 19 Emerging Therapies: a look at the current data: ALIGN

EP. 20 Emerging Therapies: a look at the current data: APPLAUSE

EP. 20 Emerging Therapies: a look at the current data: APPLAUSE

EP. 21 Emerging Therapies: a look at the current data: PROTECT study

EP. 21 Emerging Therapies: a look at the current data: PROTECT study

EP. 22 Emerging Therapies: a look at the current data: NefIgArd study

EP. 22 Emerging Therapies: a look at the current data: NefIgArd study

EP. 23 Implementing New IgAN Therapies Into Clinical Practice

EP. 23 Implementing New IgAN Therapies Into Clinical Practice

EP. 24 Shared Decision-Making for IgAN Treatment

EP. 24 Shared Decision-Making for IgAN Treatment

EP. 25 Summary and Closing Remarks

EP. 25 Summary and Closing Remarks

Please discuss the clinical implication and the effect on treatment landscape following the approval of atrasentan.

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