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This Year In Medicine 2025

Opinion|Videos|August 28, 2024

Mifeprestone for Treatment of Hypercortisolism

Author(s)Natalie Bellini, DNP, FNP-BC, BC-ADM, CDCES, Ralph DeFronzo, MD , Athena Philis-Tsimikas, MD

Experts discuss the CATALYST study's evaluation of mifepristone for hypercortisolism patients with hard-to-manage type 2 diabetes, its mechanism of action, suitable patient populations, treatment approaches for those with adrenal tumors, and factors determining surgical candidacy.

Episodes in this series

EP. 1 Overview of the CATALYST Study for Hypercortisolism

EP. 1 Overview of the CATALYST Study for Hypercortisolism

EP. 2 Defining Difficult to Control Diabetes

EP. 2 Defining Difficult to Control Diabetes

EP. 3 CATALYST Trial Study Design

EP. 3 CATALYST Trial Study Design

EP. 4 True Prevalence of Hypercortisolism

EP. 4 True Prevalence of Hypercortisolism

EP. 5 Coexisting Cardiometabolic Conditions and Hypercortisolism

EP. 5 Coexisting Cardiometabolic Conditions and Hypercortisolism

EP. 6 Engaging Primary Care Clinicians in Screening for Hypercortisolism

EP. 6 Engaging Primary Care Clinicians in Screening for Hypercortisolism

EP. 7 Spectrum of Hypercortisolism Presentations

EP. 7 Spectrum of Hypercortisolism Presentations

EP. 8 Mifeprestone for Treatment of Hypercortisolism

EP. 8 Mifeprestone for Treatment of Hypercortisolism

EP. 9 Reconsidering Standard of Care for Hypercortisolism

EP. 9 Reconsidering Standard of Care for Hypercortisolism

Video content above is prompted by the following:

• Part 2 of the CATALYST study will assess the safety and efficacy of mifepristone treatment in patients with hypercortisolism who have difficult-to-control type 2 diabetes. Can you explain how mifepristone works to control hypercortisolism? For which patients would this treatment be appropriate?
• The catalyst study also showed that a quarter of the patients with hypercortisolism had an adrenal tumor. What would be the best way to treat these patients?
• Which patients would not be good candidates for surgery?

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