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This Year In Medicine 2025

Opinion|Videos|April 18, 2025

Oral JAK Inhibitor Dose Escalation in Atopic Dermatitis Treatment

Author(s)Linda Stein Gold, MD, Lisa Swanson, MD, PhD, James Song, MD

Experts discuss how clinical judgment guides the decision to increase the dose of a JAK inhibitor, considering factors like patient response and symptom severity, and how often dose escalation is implemented in practice based on individual patient needs.

Episodes in this series

EP. 1 The Role of the JAK/STAT Signaling Pathway in Atopic Dermatitis

EP. 1 The Role of the JAK/STAT Signaling Pathway in Atopic Dermatitis

EP. 2 JAK1 Selective Inhibition and the Impact of Selectivity on Efficacy and Safety

EP. 2 JAK1 Selective Inhibition and the Impact of Selectivity on Efficacy and Safety

EP. 3 Long-Term Efficacy and Safety of JAK Inhibitors in Atopic Dermatitis

EP. 3 Long-Term Efficacy and Safety of JAK Inhibitors in Atopic Dermatitis

EP. 4 Understanding the Origins of the Boxed Warning for JAK Inhibitors

EP. 4 Understanding the Origins of the Boxed Warning for JAK Inhibitors

EP. 5 Communicating With Patients on the Safety of JAK Inhibitors in Atopic Dermatitis

EP. 5 Communicating With Patients on the Safety of JAK Inhibitors in Atopic Dermatitis

EP. 6 Laboratory Monitoring Plans for Oral JAK Inhibitors

EP. 6 Laboratory Monitoring Plans for Oral JAK Inhibitors

EP. 7 Oral JAK Inhibitors’ Place in Atopic Dermatitis Guidelines

EP. 7 Oral JAK Inhibitors’ Place in Atopic Dermatitis Guidelines

EP. 8 Utilizing Patient Factors to Guide Treatment Selection in Atopic Dermatitis

EP. 8 Utilizing Patient Factors to Guide Treatment Selection in Atopic Dermatitis

EP. 9 Addressing Treatment Response and Switching Among Systemic Therapies in Atopic Dermatitis

EP. 9 Addressing Treatment Response and Switching Among Systemic Therapies in Atopic Dermatitis

EP. 10 Oral JAK Inhibitor Dose Escalation in Atopic Dermatitis Treatment

EP. 10 Oral JAK Inhibitor Dose Escalation in Atopic Dermatitis Treatment

EP. 11 Key Takeaways on the Role of Oral JAK Inhibitors in Atopic Dermatitis Management

EP. 11 Key Takeaways on the Role of Oral JAK Inhibitors in Atopic Dermatitis Management

Video content above is prompted by the following:

With JAK inhibitor therapy, the dose can be increased if needed based on clinical judgment. How do you decide when a patient should increase the dose of their JAK inhibitor?
How often do you increase to the higher dose of JAK inhibitors in practice?

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