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This Year In Medicine 2025

Opinion|Videos|March 21, 2025

JAK1 Selective Inhibition and the Impact of Selectivity on Efficacy and Safety

Author(s)Linda Stein Gold, MD, Lisa Swanson, MD, PhD, James Song, MD

Experts discuss the significance of using selective JAK1 inhibitors for atopic dermatitis (AD), noting their targeted action compared with nonselective JAK inhibitors, and how JAK1 selectivity enhances both the efficacy and safety of these agents in treating AD.

Episodes in this series

EP. 1 The Role of the JAK/STAT Signaling Pathway in Atopic Dermatitis

EP. 1 The Role of the JAK/STAT Signaling Pathway in Atopic Dermatitis

EP. 2 JAK1 Selective Inhibition and the Impact of Selectivity on Efficacy and Safety

EP. 2 JAK1 Selective Inhibition and the Impact of Selectivity on Efficacy and Safety

EP. 3 Long-Term Efficacy and Safety of JAK Inhibitors in Atopic Dermatitis

EP. 3 Long-Term Efficacy and Safety of JAK Inhibitors in Atopic Dermatitis

EP. 4 Understanding the Origins of the Boxed Warning for JAK Inhibitors

EP. 4 Understanding the Origins of the Boxed Warning for JAK Inhibitors

EP. 5 Communicating With Patients on the Safety of JAK Inhibitors in Atopic Dermatitis

EP. 5 Communicating With Patients on the Safety of JAK Inhibitors in Atopic Dermatitis

EP. 6 Laboratory Monitoring Plans for Oral JAK Inhibitors

EP. 6 Laboratory Monitoring Plans for Oral JAK Inhibitors

EP. 7 Oral JAK Inhibitors’ Place in Atopic Dermatitis Guidelines

EP. 7 Oral JAK Inhibitors’ Place in Atopic Dermatitis Guidelines

EP. 8 Utilizing Patient Factors to Guide Treatment Selection in Atopic Dermatitis

EP. 8 Utilizing Patient Factors to Guide Treatment Selection in Atopic Dermatitis

EP. 9 Addressing Treatment Response and Switching Among Systemic Therapies in Atopic Dermatitis

EP. 9 Addressing Treatment Response and Switching Among Systemic Therapies in Atopic Dermatitis

EP. 10 Oral JAK Inhibitor Dose Escalation in Atopic Dermatitis Treatment

EP. 10 Oral JAK Inhibitor Dose Escalation in Atopic Dermatitis Treatment

EP. 11 Key Takeaways on the Role of Oral JAK Inhibitors in Atopic Dermatitis Management

EP. 11 Key Takeaways on the Role of Oral JAK Inhibitors in Atopic Dermatitis Management

Video content above is prompted by the following:

The 2 approved oral JAK inhibitors for AD are selective for JAK1. What is the significance of using a selective JAK inhibitor in AD?
How do these agents differ from nonselective JAK inhibitors used in other disease states?
How does this JAK1 selectivity impact the efficacy and safety of these agents in AD?

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