Anticholinergics Increase Dementia Risk in Middle-Aged, Older Adults
Taking daily anticholinergic drugs when 55 or older increases the risk of dementia, according to this nested case-control study.
Pediatric-Onset MS Exhibits Worse Cognitive Symptoms than Adult-Onset
When onset occurs before the age of 18, multiple sclerosis causes more severe cognitive impairment than in equivalent adult-onset cases.
FDA Approves Symdeko Tablets for Ages 6 and Older
The FDA had previously only certified Symdeko tablets for treatment of children aged 12 years and older.
Study: Rheumatoid Arthritis Associated with Neural Phenotypes
A new study reframes rheumatoid arthritis, broadly considered to be a connective tissue disorder, as having deeper neurological ties.
Guselkumab Effective for Psoriatic Arthritis Symptoms
A pair of phase 3 studies showed 20% symptomatic improvement in patients with psoriatic arthritis who were treated with guselkumab.
Heike Gerger, PhD: Further Studies of PTSD Treatment Needed
The lead investigator of a new meta-analysis shared the critical need for further studies on psychotherapeutic versus pharmacological treatments for PTSD.
Study: Evidence Supporting Preferred PTSD Treatments is Lacking
A new meta-analysis showed that while psychotherapeutic treatments are generally preferred, there’s a dearth of data with which to defend that decision.
Elderly Osteoporotic Women 3 Times More Likely to Fracture Hip
Even when comorbidities or poor prognosis are considered, osteoporosis specifically, severely raises the risk of hip fracture for women aged 80 or older.
Apremilast Helps Achieve Low Psoriatic Arthritis Disease Activity or Remission
A trio of phase 3 psoriatic arthritis trials showed that 30 mg of apremilast, twice daily, increased the likelihood of achieving low disease activity or remission.
Infliximab, Golimumab Both Effective for Ankylosing Spondylitis
A new study of long-term data demonstrates that infliximab and golimumab are both effective, safe treatments for symptoms of ankylosing spondylitis.
Bisphosphonate Use Before Denosumab Reduces Rebound Risk
The new study indicated that administration of a bisphosphonate before denosumab treatment, rather than at discontinuation, was far more effective at preventing rebound.
Baricitinib Maintains Established Safety Profile
Assorted trials and a long-term exposure study of 3770 patients with rheumatoid arthritis further demonstrate baricitinib’s previously recorded safety profile.
Cosentyx Stops or Lessens Psoriatic Arthritis Symptoms, Studies Show
A FUTURE 5 trial and MAXIMIZE trial demonstrate that Cosentyx frequently stops radiographic progression and lessens axial manifestations, respectively.
Timothy J. Wilt, MD: Behind the Updated ACP Guidelines
The ACP's guideline committee chair discusses the thought process that went into their own update on clinical standards of guidance.
American Adults with HBV, HCV Infection Largely Unaware
Less than half of US adults with either HBV or HCV infection are aware of their condition, and even among those aware, few receive appropriate treatment.
Pertussis Vaccine Effectiveness Wanes Over Time
Kaiser Permanente Northern California’s study shows that the pertussis vaccine weakens as time passes after a patient's most recent vaccination.
Lemborexant Shows Promise for Sleep Disorders
Experimental drug lemborexant underwent several phase 3 studies presented at the annual SLEEP 2019 meeting.
American College of Physicians Details Methods for Creating Guidelines
The American College of Physicians (ACP) released a paper detailing their methods for creating clinical guidelines and guidance statements.
Brief Hospitalization No More Effective Than Standard Treatment for Self-Harm or Suicidality
Patients who self-referred themselves to a hospital for suicidal and/or self-harming actions did not improve more than patients who received standard treatment apart from hospitalization.
Direct-Acting Antivirals Don't Increase Adverse Events in Hepatitis C Treatment
A new study debunks preceding fears that direct-acting antivirals increase the likelihood of adverse events for patients with the hepatitis C virus.
Ruben Mesa, MD: Ruxolitinib as a Myelofibrosis Treatment
Ruben Mesa, MD, director of the Mays Cancer Center at UT Health San Antonio MD Anderson Cancer Center, discusses treating myelofibrosis with ruxolitinib therapy.
Ruben Mesa, MD: Myelofibrosis Patients Frequently Present Symptoms
Ruben Mesa, MD, director of the Mays Cancer Center at UT Health San Antonio MD Anderson Cancer Center, discusses the visible symptoms and diagnosis process for patients with myelofibrosis.
Phosphodiesterase 10A Decreases Alongside Dopamine in Parkinson Disease
A new study shows that loss of phosphodiesterase, not just dopamine, indicates a worsening of motor symptoms in patients with Parkinson disease.
Ocular iStent Implant Improves Cataract Surgery for Glaucoma
Patients who received the implant in addition to the surgery showed more positive results than the control group in a randomized, single-masked study.
FDA Approves Gore Medical Cardioform ASD Occluder
The new occluder, which can repair both small and large cardiovascular defects, received premarket approval.
In-Utero and Perinatal Conditions Could Influence Suicide Risk, Meta-Analysis Shows
A new study found that elements such as birth order, low parental education, or low birthweight could increase suicide risk throughout a person’s lifespan.
New Immunotherapy Blocks Key Macrophage Checkpoint in AML Care
Hu5F9-G4, aided by azacytidine, showed the potential to remove signals on cancer cells that would normally prevent a patient’s body from eliminating said cells.
Low-Income, Female Patients Likely to Face Delayed Leukemia Diagnoses
New analysis shows patients from either of these populations often take longer to be diagnosed with leukemia or lymphoma than their male or median-income counterparts.
Adenoid Cystic Carcinoma Does Not Vary According to Race, Gender
A new study shows a profound lack of genetic markers, allowing doctors to standardize treatment.
Rituximab Infusion Side Effects Abated by Rupatadine, Montelukast
A new study shows that adding this pair of drugs reduces costs and side effects while increasing efficacy.
2 Clarke Drive Cranbury, NJ 08512