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Visual Dx:  Weight Gain, Fatigue, and Cold Sensitivity ...Can You Diagnose This

A 25-year-old female visited her primary care physician complaining about weight gain over the past 2 and a half months. She has not had any changes with diet or exercise, yet she has gained 10 pounds. She also has had chronic fatigue over this period and has recurring constipation. Her skin appears pale and she mentions feeling extreme cold sensitivity, even when the temperature of a room feels fine to others.

The Human Body Has Internal Scale to Sense Body Weight Says Study

It has been suggested that the human body has an intrinsic weight sensor that functions as part of energy homeostasis.  Information about body weight is used to drive caloric intake and metabolic expenditure with the goal of maintaining body weight at a specific set point, however little is known about how such a sensor might function. In a recent paper, published in the journal EClinicalMedicine researchers from the University of Gothenburg, Sweden, have devised a method to investigate this system they have dubbed the “graviostat,” using weighted vests.

The Obesity Algorithm: Why Weight Management May Be More Important Now Than Ever

Obesity-related conditions seem to worsen the effect of COVID-19. The Centers for Disease Control and Prevention (CDC) reported that people with heart disease and diabetes are at higher risk of COVID-19 complications, and the World Obesity Organization predicts that a large percentage of patiients with the coronavirus will have a BMI over 25.  Many aspects of patient management can be more difficult in the obese patient, including diagnostic imaging, intubation, positioning, and transport, making it more important than ever for patients and their physicians to prioritize weight management strategies.

Impact of ACEi/ARBs in COVID-19 Patients The Focus of New Clinical Trial

In an effort to settle the debate surrounding the use of ACE inhibitors (ACEI) and ARBs during the ongoing coronavirus disease 2019 (COVID-19) outbreak, investigators from Perelman School of Medicine at the University of Pennsylvania, recently launched a new clinical trial.  The REPLACE COVID trial plans to recruit 152 hospitalized patients already taking medications from the classes, with the goal of determining whether discontinuing use affects the severity of disease symptoms.