Internal Medicine

Study results show that treatment with a proton pump inhibitor does not reduce the effectiveness of metformin treatment in patients with type 2 diabetes.

"Beauty is in the eyes of the beholder" and "seeing the same glass as being half-empty or half-full" are two commonly cited adages and nowhere is their meaning more evident than in the ongoing debate of whether a pelvic examination should be part of the routine check-up of a female patient.

This 23-year-old man developed these lesions on his feet during a 10-month stay in Nicaragua. Initially he had itching and burning. He has been treated with 3 courses of topical antifungal preparations and there is no significant past medical history other than sweaty feet.

Slam dunking basketball player reports pain in his left foot and undergoes exams to determine the cause of the problem

A 58 year old G2P2, married woman presents to your office for her annual well woman exam. Upon questioning, she tells you that for several months she's been having trouble with urinary leaking. "I just can't seem to get to the bathroom on time and I feel like I go more often than usual." She also has been urinating at least twice during the night. She denies urinary burning or dysuria

Efficacy of anti-inflammatory or antibiotic treatment in patients with non-complicated acute bronchitis and discoloured sputum: randomised placebo controlled trial

This review and meta-analysis assessed whether antiviral treatment given during the acute herpes zoster rash is effective at preventing postherpetic neuralgia in patients with a first-time case of shingles.

A generic version of Gilead Science's hepatitis C drug Sovaldi will be produced in India and sold there and in other poorer countries at what is likely to be a fraction of what it costs in the United States.

New research indicates that doctors who treat anaphylaxis with intravenous epinephrine rather than intramuscular or subcutaneous injections are increasing the risk that patients will suffer overdoses or other adverse reactions.

Although methadone accounts for only 2% of opioid prescriptions, it caused nearly one in 3 prescription opioid overdose deaths in 2012, a 6-fold increase from 2009, according to the CDC.

Because there is no objective test for pain, and because each patient's experience of his or her painful condition is subjective and unique, physicians who treat these patients must process a variety of symptoms, signs, and cues to determine whether they can trust their patient's narrative.

In this edition of Clinical Forum, we asked 3 Cardiology Review editorial board members to comment on the role of renal denervation following the publication of the SYMPLICITY HTN-3 trial results.

The 74th Scientific Sessions of the American Diabetes Association (ADA) brought together more than 17,300 attendees from more than 121 countries. This year's program included 96 symposia, 50 oral abstract sessions, 10 interest group discussions, 18 meet-the-expert sessions, and 10 special lectures and addresses. Cardiology Review is covering 6 of the top sessions.

Stendra (avanafil) is now the only FDA-approved erectile dysfunction (ED) medication indicated to be taken as early as approximately 15 minutes before sexual activity.

Fumaric acid esters (FAEs) are a known component of a centuries-old herbal medicine, have been used for over 50 years as a topical treatment for psoriasis, and most recently, have demonstrated efficacy in treating relapsing- remitting multiple sclerosis.

Movantik (naloxegol), an oral peripherally acting mu-opioid receptor antagonist, has been approved by the FDA for the treatment of opioid-induced constipation in adults with chronic non-cancer pain.

Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) is a treatment option for chronic weight management in addition to a reduced-calorie diet and physical activity.

The first accurate measurements of ideal growth and developments from conception to birth depicting a healthy pattern of growth desirable for all fetuses and newborns regardless of ethnic origin have been published in The Lancet.

Symptomatic severe aortic valve stenosis reduces life expectancy and prompts the need for aortic valve replacement, which can be done 2 ways.

The case of the "Mississippi baby," who was deemed HIV-free but relapsed 2 years after ceasing treatment, adds to evidence researchers can use to find an effective cure.

Drug formerly known as Zerenex gets approval following Phase 3 clinical trials

Although the incidence of perioperative cardiac arrest primarily attributable to anesthesia is less than 1 per 10,000 anesthetics, it represents the most serious complication and can have devastating results, as witnessed by the recent death of comedian Joan Rivers.

New research suggests that oral immunotherapy may trigger anaphylaxis in an unusually high percentage of asthmatic teenagers with high-risk food allergies who failed to adhere to their management plan.

This study was designed to determine the dose-response relation between fruit and vegetable consumption and risk of all cause, cardiovascular, and cancer mortality.

This 70-year-old woman was referred for this waxing and waning erythematous facial rash of two years duration. She has tried topical metronidazole and clindamycin without improvement. Her past medical history is significant for hypertension and hypothyroidism, otherwise she is in good health and a review of systems is negative except for the itching facial rash.