The HCPLive nephrology page is a resource for medical news and expert insights on kidney disease. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments in nephrology, and more.
July 25th 2024
The sNDA for furosemide seeks to expand the indication to include the treatment of edema due to fluid overload in patients with CKD, with a PDUFA date of March 6, 2025.
Expert Illustrations & Commentaries™: Exploring the Role of Novel Agents for the Management of IgA Nephropathy
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‘REEL’ Time Patient Counseling™: Navigating the Complex Journey of Diagnosing and Managing Fabry Disease
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Patient, Provider & Caregiver Connection™: Implementing an Effective Management Plan to Improve Outcomes in IgA Nephropathy
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Approval for Hemodialysis Drug
The US Food and Drug Administration approved ferric pyrophosphate citrate (Triferic/Rockwell) for use as an iron replacement therapy in patients with end-stage renal disease, the company announced. It is also indicated for chronic kidney disease. The drug is for adults.
More Intensive Blood Pressure Goals Reserved for Most Severe Kidney Disease: KDIGO
November 17th 2014Recent updates by the 8th Joint National Committee (JNC 8), the American and International Societies of Hypertension (ASH-ISH), and KDIGO recommend target blood pressure of less than 140/90 mm Hg for most individuals, including those with CKD.
Updated Blood Pressure Guidelines from Major Bodies Agree on Targets in Kidney Disease
November 17th 2014Two major sets of hypertension guidelines released in 2014 contain more common threads than differences, and are intended to serve different purposes. Clinicians seeking guidance for managing hypertension in chronic kidney disease (CKD) can look for this common ground to avoid "guideline overload."
Hypertension Guidelines Still Leave Room for Clinical Judgment
November 17th 2014Guidelines for hypertension have converged on a blood pressure target of less than 140/90 mm Hg for most individuals with chronic kidney disease (CKD). However, studies still need to clarify optimal BPs for advanced disease and optimal cardiovascular prevention.
Pharmacogenetics Helps Fine-Tune Warfarin Dosing in Kidney Disease
November 16th 2014Though warfarin has long been the mainstay of anticoagulation in atrial fibrillation (AF), dosing is complicated by a host of factors, and the drug has a famously narrow therapeutic range. One way to fine-tune warfarin therapy is to account for genetic variation.
Consider Individual Risks, Benefits for Anticoagulation in Chronic Kidney Disease
November 15th 2014Anticoagulation is recommended for members of the general population with atrial fibrillation, but its significant risks must be weighed carefully in the medically fragile chronic kidney disease population.
Atrial Fibrillation Associated with Accelerated Renal Disease; Ablation May Help
November 15th 2014Treatment of atrial fibrillation (AF) in patients with CKD may help prevent disease progression. Ablation has been shown produce marked improvement in kidney function as measured by eGFR. A prospective study of individuals undergoing catheter ablation for AF showed that most patients remained AF-free, and that eGFR improved significantly for those with persistent or longstanding persistent AF.
Cinacalcet May Reduce Cardiovascular Risk for Older Kidney Disease Patients: EVOLVE Re-Analysis
November 14th 2014Secondary hyperparathyroidism can occur in CKD when the kidney loses its ability to produce active metabolites of vitamin D, and reduces phosphorus excretion. Cinacalcet seeks to interrupt the progression to severe unremitting hyperparathyroidism by mimicking calcium to the calcium-sensing receptors that control parathyroid hormone levels.
Diabetic Kidney Disease: New Consensus Document
October 22nd 2014Prompted by almost-epidemic rates of diabetes in the United States and globally, the American Diabetes Association recently convened a consensus panel to examine diabetic kidney disease, one of the most frequent complications associated with diabetes.
Metformin Inappropriately Prescribed to Older Diabetics with Chronic Kidney Disease
July 28th 2014Clinicians must anticipate changes in kidney function during acute illness and surgical procedures, as well as frequently reassess metformin use in older patients, since kidney function declines predictably with age.
Bioengineered Blood Vessel Offers Potential Improvements for Dialysis Patients
November 21st 2013Initial results from human clinical trials involving the use of bioengineered blood vessels could point the way to cost-effective alternative therapies for hemodialysis patients with end-stage renal disease.
Vascular Calcification Shown on X-Ray Assesses Cardiovascular Risks in Chronic Kidney Disease
November 8th 2013A recent study presented at Kidney Week 2013 suggests that a plain X-ray is a reliable and inexpensive tool for assessing the risks of cardiovascular events and death in patients who have chronic kidney disease (CKD) and are not on dialysis.
Study Shows Tolvaptan is Effective in Treating Autosomal Dominant Polycystic Kidney Disease
November 4th 2012Results from the TEMPO trial presented at Kidney Week 2012 show that treatment with tolvaptan slowed the increase in total kidney volume and the decline in kidney function in patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD).