Type 2 Diabetes

After new data from the Diabetes Prevention Program Outcomes Study suggested neither metformin nor lifestyle intervention addressed the cardiovascular risk in patients with prediabetes, we asked experts at ADA 2022 if it was time to rethink metformin as first-line therapy in type 2 diabetes.

Although typically associated with an increased risk of type 2 diabetes, new research from Israel presented at ADA 2022 suggests increased BMI in adolescence was associated with an increased risk of new-onset type 1 diabetes in young adulthood.

A 5-year, real-world study comparing the safety and efficacy of empagliflozin against other glucose-lowering agents, EMPRISE suggests empagliflozin was associated with relative risk reductions for heart failure hospitalization greater than 50% compared with DPP-4 inhibitors and greater than 30% compared with GLP-1 receptor agonists.

The mean time below range following exercise sessions was significantly lower with IGlar U300 compared to IDEG at the 100% dose.

Hiddo Heerspink, PharmD, PhD, discusses a SURPASS-4 analysis examining kidney outcomes among patients receiving tirzepatide vs insulin glargine and provides perspective on the next steps for research as well as education.

At ADA 2022, Endocrinology Network sat down with Lindsay Mayberry, PhD, to discuss a pair of studies she presented examining trends in CGM uptake and correlates associated with increased uptake in primary care settings.

The late-breaking findings at ADA 2022 suggest patients were more often prescribed oral semaglutide by primary care physicians than endocrinologists.

Prof. Hertzel Gerstein discusses new ELIXA biomarker findings from ADA 2022.

However, the post-hoc analysis found a greater variability in HbA1c levels was associated with increased risk of cardiorenal outcomes.

The diabetologist and professor discusses new findings from the ReTUNE trial, which disparage the utility of BMI in defining diabetes risk and remission opportunity.

New post hoc data from the STEP 1 and 4 trials show an approximate 60% risk reduction of type 2 diabetes over 10 years versus placebo.

A new report from the CDC that examined 20-year trends in vision impairment among patients with diabetes suggests the rate of decline in vision impairment began to plateau in 2012 and may be on the rise in recent years.

New research from a review assessing risk of long COVID in patients with diabetes suggests the risk of developing long COVID in these patients could be more than 4-fold greater than the risk among patients without diabetes.

W. Timothy Garvey discusses the results of a study leveraging data from STEP 1 and STEP 4 to determine the reduction in 10-year risk of type 2 diabetes seen with use of semaglutide 2.4 mg vs placebo therapy.

Data from the AWARD-PEDS study presented at ADA 2022 suggest once-weekly dulaglutide could improve glycemic control in youth with type 2 diabetes, with a safety profile consistent with that observed in adult patients.

A greater reduction in UACR was observed with finerenone in patients taking GLP-1RA at baseline.

An analysis of SURPASS-4 data presented at ADA 2022 details the apparent reduction in progression of chronic kidney disease observed with use of tirzepatide compared to insulin glargine in the phase 3 trial, with a 41% reduction in progression of CKD in T2D.

During the opening press conference, Endocrinology Network got perspective from a trio of American Diabetes Association executives on the prospect of tirzepatide as an agent for combatting both diabetes and obesity.

Ahead of ADA 2022, our editorial staff offers a quick glimpse into some of the hot topics to look out for ahead of the American Diabetes Association's 82nd Scientific Sessions, including new approaches to managing renal risk, a potential game-changer in obesity, and more.

Naomi Fisher, MD, offers perspective on the changing landscape of diabetes management and how the addition of new agents to the ADA's Standards of Care might impact care of patients.

The FreeStyle Libre 3 system, which is billed by Abbott as the world's smallest, thinnest, and most accurate 14-day glucose sensor, received FDA clearance on May 31 and is expected to be available in participating pharmacies later this year.

The American Diabetes Association released updates to their Standards of Care to reflect new data regarding the cardiovascular and renal benefits of agents, including finerenone and SGLT2 inhibitors.

An analysis of data from more than 75,000 patients with diabetic kidney disease details the risk of fracture among new users of SGLT2 inhibitors compared to new users of DPP-4 inhibitors.

In his most recent column, Dr. Gregory Weiss provides breaks down a recent study that provided an overview of all-cause and cause-specific mortality among patients with diabetes before and during the COVID-19 pandemic.

Our endocrine month in review spotlights the most popular articles from the past month. This month's top articles include the approval of tirzepatide, news from AACE & ATTD, and a pair of podcast episodes.