Cardiology

Pivotal clinical trial costs increased if more patients were needed to document treatment benefit, if active drug comparators were used, or to measure clinical end points rather than a change in a surrogate outcome.

The capsules of icosapent ethyl, which is derived from fish, showed a 25% relative risk reduction compared to placebo.

Lucia Novak discusses the importance of testing for cardiovascular outcomes of diabetes treatments and compares the cardiovascular effects of several diabetes drugs.

A novel new study shows probands of African and Hispanic descent with EOAF are more likely to have a first-degree relative with arrhythmia when compared to their European counterparts.

The FDA has been granting priority review to more pipeline drugs without skimping on application standards. What makes up a viable novel therapy application, specialty by specialty?

A placebo-controlled study of daily low-dose aspirin found that treatment did not prolong healthy living in older adults. In fact, aspirin use was associated with increased risk of major hemorrhage.

Symptoms of cardiovascular disease, including intima-media thickness and coronary artery calcium, were more common in patients with HIV and cytomegalovirus.

The device is a balloon catheter designed to treat rare, but life-threatening perforations in the coronary artery, which can occur during Percutaneous Coronary Intervention procedures.

The supplemental BLA seeks FDA approval for alirocumab (Praulent) as a treatment to reduce overall risk of major adverse cardiovascular events.

Interestingly, increased distress led to a higher risk of stroke for women, while distressed men had a higher risk of heart attack.

Mice treated with ACE inhibitors demonstrated preservation of cognitive function, preserved dendritic complexity, a normal spine number, and significantly less microglial activation.

The risk of acute coronary syndrome recurring after hospitalization was not found to be increased in individuals infected with HIV.

Though previous research showed telemonitoring and pharmacist consultation helped patients manage blood pressure for about one year, researchers have been unsure whether it would provide sustained, long-term benefits in at-risk patients.

Deaths due to drug overdoses and suicides have contributed to decreasing US life expectancy, but other factors indicate that there is a deeper root cause driving these trends.

The CDC reports that, while tobacco use has decreased, cardiovascular disease risk factors and rates of cardiovascular management are still in need of improvement.

Preliminary findings from WTC Health Program are the first to make the connection among workers at "Ground Zero."

Ticagrelor 60 mg and 90 mg tablets have been indicated for lowering the risk of heart attack, or death from heart attack or stroke in patients with acute coronary syndrome.

Study of abrupt versus gradual reduction of nicotine informs FDA-proposed rule on reducing cigarette nicotine to "minimally addictive" levels.

The heart rhythm specialist with the UVA Advanced Imaging group discussed his team's early successes with Medtronic's heart ablation vest.

In a phase 2/3 trial, the Bayer Pharmaceuticals therapy demonstrated protection from bleeding and patient safety for up to a median of 1.9 years.

Is there a link between vitamin D deficiency and mortality in patients with heart failure? A new study may have the answer. 

Stem cell research from the University of Michigan reveals dangerous cardiac effects of a gene mutation in patients with Dravet syndrome.

How the conflicting results of the ASCEND trial are actually much more determinant than they appear, and critical in the scope of treating comorbidities in patients with diabetes.

In a 15,000-plus patient analysis that spanned more than 7 years, aspirin reduced vascular risks in patients—but also increased their rate of major bleeding events.

Patients administered the FDA-approved therapy reported tripled rates of weight-loss, along with noninferiority for risk of major cardiovascular events, over 1 year and an extension period.