Cardiology

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A 36-year-old man presents to his primary care physician's office for follow-up after being told he had an abnormal ECG at a health fair he attended. He has no complaints. He is sedentary and does not participate in any exercise or athletic activity.

Dr. Arruda is a hematology researcher at The Children's Hospital of Philadelphia and an associate professor of Pediatrics in the Perelman School of Medicine at the University of Pennsylvania. His laboratory focuses on gene-based strategies for the treatment of bleeding and thrombotic diseases.

There is consistent observational data that identifies concomitant use of proton pump inhibitors for gastroesophageal reflux disease and clopidogrel following acute coronary syndrome increases the risk of recurrent cardiovascular events. While a variety of theories exist (lower pH alters absorption, etc.), no clear factor has been identified.

This prospective epidemiological study compares the capabilities of the new 2013 American Heart Association and American College of Cardiology ASCVD risk calculator against several alternative cardiovascular risk calculators and explores the potential effect of preventive therapy on risk overestimation in the AHA-ACC-ASCVD model.

The Paleolithic (grain-free) diet is gathering steam among dieters and health conscious individuals alike. Proponents consume only items that, hypothetically, cavemen would have had access to. They claim that modern man can't metabolize comparatively new types of food, and our reliance on processed foods has increased rates of obesity, heart disease, and diabetes.