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Spotlight -

This Year In Medicine 2025

Opinion|Videos|November 13, 2024

Presentation and Diagnosis of PBC

Author(s)Nancy Reau, MD, John Vierling, MD, FACP, FAASLD, AGAF, Aparna Goel, MD

Key Takeaways

Fatigue and pruritus are the most common symptoms of PBC, while jaundice and xanthomas are less common.
Diagnosis involves clinical evaluation, laboratory tests, and imaging studies to confirm PBC and exclude other liver diseases.
Elevated alkaline phosphatase and presence of antimitochondrial antibodies are key laboratory markers for PBC diagnosis.
Liver biopsy may be used to confirm diagnosis and assess disease stage, aiding in management decisions.

SHOW MORE

The panelists discuss the typical presentation of primary biliary cholangitis (PBC), covering common and uncommon symptoms, the diagnostic journey, and key clinical and laboratory assessments used to identify disease markers.

Episodes in this series

4 experts are featured in this series.

EP. 1 Pathophysiology of PBC

4 experts are featured in this series.

EP. 2 Presentation and Diagnosis of PBC

4 experts are featured in this series.

EP. 3 Differential Diagnosis of PBC

4 experts are featured in this series.

EP. 4 Disease Progression and Extrahepatic Manifestations of PBC

4 experts are featured in this series.

EP. 5 Second-Line Treatments and Management of Symptoms in PBC

4 experts are featured in this series.

EP. 6 Treatment Goals and First-Line Therapy in PBC

4 experts are featured in this series.

EP. 7 Seladelpar for Treatment of PBC

4 experts are featured in this series.

EP. 8 PPAR Agonists for Treatment of PBC

4 experts are featured in this series.

EP. 9 Elafibranor and Choosing Amongst PPAR Agonists in PBC

4 experts are featured in this series.

EP. 10 Pruritus Control With PPAR Agonists in PBC

4 experts are featured in this series.

EP. 11 Integration of PPAR Agonists in Treatment Landscape of PBC

4 experts are featured in this series.

EP. 12 Treatment Response to PPAR Agonists and Other Therapies in PBC

4 experts are featured in this series.

EP. 13 Thoughts on the Current State of PBC Management

4 experts are featured in this series.

EP. 14 Outcomes and Adoption of PPAR Agonists in PBC

Video content above is prompted by the following:

How do patients typically present
with PBC? What are the most and least common symptoms of the disease?
What is the typical path to a diagnosis for patients with PBC?
What clinical and laboratory assessments do you perform, and what markers do you look for?

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