Disease Progression and Extrahepatic Manifestations of PBC

Key Takeaways

• Vitamin deficiencies, especially fat-soluble ones, are prevalent in PBC due to malabsorption issues.
• Osteoporosis is a major concern in PBC, often linked to chronic cholestasis and vitamin D deficiency.
• MASH can co-occur with PBC, further complicating liver health and management.
• Autoimmune conditions, like Sjögren's syndrome and thyroid disorders, frequently accompany PBC.
• Obesity exacerbates liver disease progression in PBC, complicating management strategies.