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This Year In Medicine 2025

Opinion|Videos|December 11, 2024

Pruritus Control With PPAR Agonists in PBC

Author(s)Nancy Reau, MD, John Vierling, MD, FACP, FAASLD, AGAF, Aparna Goel, MD

Key Takeaways

Pruritus affects over 80% of PBC patients, impacting quality of life and treatment adherence. Effective management is essential for improving patient outcomes.
Addressing pruritus involves pharmacological treatments and lifestyle changes, tailored to individual patient needs, to alleviate symptoms and enhance well-being.
Long-term management of PBC requires a comprehensive approach, integrating symptom control with disease-modifying therapies to prevent complications and improve overall patient care.

SHOW MORE

The panel of experts discuss the role of effectively treating pruritus, a common and debilitating symptom in over 80% of patients with cholestatic liver diseases like primary biliary cholangitis (PBC), and its importance in the long-term management of the disease.

Episodes in this series

4 experts are featured in this series.

EP. 1 Pathophysiology of PBC

4 experts are featured in this series.

EP. 2 Presentation and Diagnosis of PBC

4 experts are featured in this series.

EP. 3 Differential Diagnosis of PBC

4 experts are featured in this series.

EP. 4 Disease Progression and Extrahepatic Manifestations of PBC

4 experts are featured in this series.

EP. 5 Second-Line Treatments and Management of Symptoms in PBC

4 experts are featured in this series.

EP. 6 Treatment Goals and First-Line Therapy in PBC

4 experts are featured in this series.

EP. 7 Seladelpar for Treatment of PBC

4 experts are featured in this series.

EP. 8 PPAR Agonists for Treatment of PBC

4 experts are featured in this series.

EP. 9 Elafibranor and Choosing Amongst PPAR Agonists in PBC

4 experts are featured in this series.

EP. 10 Pruritus Control With PPAR Agonists in PBC

4 experts are featured in this series.

EP. 11 Integration of PPAR Agonists in Treatment Landscape of PBC

4 experts are featured in this series.

EP. 12 Treatment Response to PPAR Agonists and Other Therapies in PBC

4 experts are featured in this series.

EP. 13 Thoughts on the Current State of PBC Management

4 experts are featured in this series.

EP. 14 Outcomes and Adoption of PPAR Agonists in PBC

Video content above is prompted by the following:

Pruritus is a debilitating symptom experienced by over 80% of patients with cholestatic liver diseases, such as PBC. What is the role of effectively treating pruritus in the long-term management of PBC?

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