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Spotlight -

This Year In Medicine 2025

Opinion|Videos|November 27, 2024

Treatment Goals and First-Line Therapy in PBC

Author(s)Nancy Reau, MD, John Vierling, MD, FACP, FAASLD, AGAF, Aparna Goel, MD

Key Takeaways

PBC treatment goals include symptom relief, disease progression prevention, and quality of life improvement, adapting to disease severity.
UDCA, the first-line treatment for PBC, enhances bile flow and reduces liver inflammation, indicated for early-stage patients.
Incomplete biochemical response to UDCA may require therapy modification, with response assessed through liver function tests after six months.

SHOW MORE

The panel of experts outline the primary treatment goals for patients with primary biliary cholangitis (PBC), detailing how goals adjust based on disease severity, the role of ursodeoxycholic acid (UDCA) as first-line therapy, and the challenges that may require therapy modifications based on biochemical response.

Episodes in this series

4 experts are featured in this series.

EP. 1 Pathophysiology of PBC

4 experts are featured in this series.

EP. 2 Presentation and Diagnosis of PBC

4 experts are featured in this series.

EP. 3 Differential Diagnosis of PBC

4 experts are featured in this series.

EP. 4 Disease Progression and Extrahepatic Manifestations of PBC

4 experts are featured in this series.

EP. 5 Second-Line Treatments and Management of Symptoms in PBC

4 experts are featured in this series.

EP. 6 Treatment Goals and First-Line Therapy in PBC

4 experts are featured in this series.

EP. 7 Seladelpar for Treatment of PBC

4 experts are featured in this series.

EP. 8 PPAR Agonists for Treatment of PBC

4 experts are featured in this series.

EP. 9 Elafibranor and Choosing Amongst PPAR Agonists in PBC

4 experts are featured in this series.

EP. 10 Pruritus Control With PPAR Agonists in PBC

4 experts are featured in this series.

EP. 11 Integration of PPAR Agonists in Treatment Landscape of PBC

4 experts are featured in this series.

EP. 12 Treatment Response to PPAR Agonists and Other Therapies in PBC

4 experts are featured in this series.

EP. 13 Thoughts on the Current State of PBC Management

4 experts are featured in this series.

EP. 14 Outcomes and Adoption of PPAR Agonists in PBC

Video content above is prompted by the following:

What are the treatment goals for patients with PBC?
- How do treatment goals change based on the severity of the disease?
UDCA is recommended as the first-line pharmacological treatment for PBC. How does it work to treat the disease?
- For which patients is it indicated?
What are some challenges or limitations you encounter when using UDCA that may prompt a need to modify therapy?
- How do you define biochemical response and when?

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