Pathophysiology of PBC

Author(s):

Nancy Reau, MD,John Vierling, MD, FACP, FAASLD, AGAF

Key Takeaways

PBC involves autoimmune-mediated destruction of intrahepatic bile ducts by autoreactive T lymphocytes, leading to cholestasis.
Accumulation of toxic bile acids due to cholestasis causes hepatocellular damage and inflammation.
Chronic inflammation from bile duct destruction results in fibrosis and cirrhosis over time.
Genetic predispositions and environmental factors play significant roles in the etiology and progression of PBC.

The panelists explain the pathophysiology of primary biliary cholangitis (PBC), highlighting how immune-mediated processes contribute to progressive liver damage in affected patients.

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