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This Year In Medicine 2025

Opinion|Videos|December 18, 2024

Treatment Response to PPAR Agonists and Other Therapies in PBC

Author(s)Nancy Reau, MD, John Vierling, MD, FACP, FAASLD, AGAF, Aparna Goel, MD

Key Takeaways

PBC involves autoimmune-mediated destruction of intrahepatic bile ducts by autoreactive T lymphocytes, leading to cholestasis.
Accumulation of toxic bile acids due to cholestasis causes hepatocellular damage and inflammation.
Chronic inflammation from bile duct destruction results in fibrosis and cirrhosis over time.
Genetic predispositions and environmental factors play significant roles in the etiology and progression of PBC.

SHOW MORE

The panel of experts discuss how to determine the effectiveness of treatment in primary biliary cholangitis (PBC), focusing on key clinical markers, biochemical responses, and patient outcomes.

Episodes in this series

4 experts are featured in this series.

EP. 1 Pathophysiology of PBC

4 experts are featured in this series.

EP. 2 Presentation and Diagnosis of PBC

4 experts are featured in this series.

EP. 3 Differential Diagnosis of PBC

4 experts are featured in this series.

EP. 4 Disease Progression and Extrahepatic Manifestations of PBC

4 experts are featured in this series.

EP. 5 Second-Line Treatments and Management of Symptoms in PBC

4 experts are featured in this series.

EP. 6 Treatment Goals and First-Line Therapy in PBC

4 experts are featured in this series.

EP. 7 Seladelpar for Treatment of PBC

4 experts are featured in this series.

EP. 8 PPAR Agonists for Treatment of PBC

4 experts are featured in this series.

EP. 9 Elafibranor and Choosing Amongst PPAR Agonists in PBC

4 experts are featured in this series.

EP. 10 Pruritus Control With PPAR Agonists in PBC

4 experts are featured in this series.

EP. 11 Integration of PPAR Agonists in Treatment Landscape of PBC

4 experts are featured in this series.

EP. 12 Treatment Response to PPAR Agonists and Other Therapies in PBC

4 experts are featured in this series.

EP. 13 Thoughts on the Current State of PBC Management

4 experts are featured in this series.

EP. 14 Outcomes and Adoption of PPAR Agonists in PBC

Video content above is prompted by the following:

How do you determine if treatment is effective in PBC?

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