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Spotlight -

This Year In Medicine 2025

Opinion|Videos|December 11, 2024

Elafibranor and Choosing Amongst PPAR Agonists in PBC

Author(s)Nancy Reau, MD, John Vierling, MD, FACP, FAASLD, AGAF, Aparna Goel, MD

Key Takeaways

Elafibranor, a PPAR-δ agonist, has demonstrated long-term efficacy and safety in treating primary biliary cholangitis (PBC).
Elafibranor and seladelpar both improve liver function in PBC, but differ in receptor selectivity and side effect profiles.
Selecting the right PPAR agonist requires evaluating patient-specific factors, including comorbidities and side effect tolerance.
Monitoring treatment efficacy involves regular liver function tests and assessing symptom improvement for optimal outcomes.

SHOW MORE

The panel of experts examine the long-term data for the recently FDA-approved PPAR-δ agonist elafibranor in the treatment of primary biliary cholangitis (PBC), comparing its clinical findings with those of seladelpar, and explores how to choose the right peroxisome proliferator-activated receptor (PPAR) agonist and assess treatment effectiveness.

Episodes in this series

4 experts are featured in this series.

EP. 1 Pathophysiology of PBC

4 experts are featured in this series.

EP. 2 Presentation and Diagnosis of PBC

4 experts are featured in this series.

EP. 3 Differential Diagnosis of PBC

4 experts are featured in this series.

EP. 4 Disease Progression and Extrahepatic Manifestations of PBC

4 experts are featured in this series.

EP. 5 Second-Line Treatments and Management of Symptoms in PBC

4 experts are featured in this series.

EP. 6 Treatment Goals and First-Line Therapy in PBC

4 experts are featured in this series.

EP. 7 Seladelpar for Treatment of PBC

4 experts are featured in this series.

EP. 8 PPAR Agonists for Treatment of PBC

4 experts are featured in this series.

EP. 9 Elafibranor and Choosing Amongst PPAR Agonists in PBC

4 experts are featured in this series.

EP. 10 Pruritus Control With PPAR Agonists in PBC

4 experts are featured in this series.

EP. 11 Integration of PPAR Agonists in Treatment Landscape of PBC

4 experts are featured in this series.

EP. 12 Treatment Response to PPAR Agonists and Other Therapies in PBC

4 experts are featured in this series.

EP. 13 Thoughts on the Current State of PBC Management

4 experts are featured in this series.

EP. 14 Outcomes and Adoption of PPAR Agonists in PBC

Video content above is prompted by the following:

The FDA recently approved another PPAR-δ agonist, elafibranor, for PBC. Could you discuss the long-term data of this agent?
- How do clinical findings for elafibranor compare with those of seladelpar?
- How do you choose the right PPAR agonist for treating PBC, and how do you know if the treatment is working?

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