Opinion|Videos|December 11, 2024
Elafibranor and Choosing Amongst PPAR Agonists in PBC
Key Takeaways
- Elafibranor, a PPAR-δ agonist, has demonstrated long-term efficacy and safety in treating primary biliary cholangitis (PBC).
- Elafibranor and seladelpar both improve liver function in PBC, but differ in receptor selectivity and side effect profiles.
The panel of experts examine the long-term data for the recently FDA-approved PPAR-δ agonist elafibranor in the treatment of primary biliary cholangitis (PBC), comparing its clinical findings with those of seladelpar, and explores how to choose the right peroxisome proliferator-activated receptor (PPAR) agonist and assess treatment effectiveness.
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Episodes in this series
Video content above is prompted by the following:
- The FDA recently approved another PPAR-δ agonist, elafibranor, for PBC. Could you discuss the long-term data of this agent?
- How do clinical findings for elafibranor compare with those of seladelpar?
- How do you choose the right PPAR agonist for treating PBC, and how do you know if the treatment is working?
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