Major Depressive Disorder

The mean level of anxiety has increased 5 points since 2017 on a 100-point scale, with Baby Boomers reporting a 7-point jump over the last year.

The drug is approved for adults with depression, but exceptionally high placebo responses rendered its effects in children not statistically significant.

Women who continued using antipsychotic medications during pregnancy had an absolute risk of 4.2% to 12% of developing gestational diabetes.

Patients that had their medication selection guided by the GeneSight pharmacogenomic testing were 50% more likely to achieve remission and 30% more likely to achieve treatment response.

John Greden, MD, discussed the challenges physicians face in diagnosing, identifying, and treating depression, and the populations that are still severely underserved.

Darrell Kirch, MD, spoke at the APA’s annual meeting about the impact physician burnout has had and what can be done to address it and to improve clinician well-being.

Firearm use in the not guilty by reason of insanity population is more closely related to substance use and personality disorder than psychotic or mood disorders.

The associated PTSD comorbidities represent a significant public health problem that’s concomitant with increased disease burden and mortality.

The use of electroconvulsive therapy in patients with bipolar depression resulted in higher remission rates while showing similar response rates to unipolar major depression.

This is the first FDA-approved antidepressant for MDD to have data in US Prescribing Information showing a positive effect on processing speed.

All told, 68% of the group receiving a full dose of MDMA no longer qualified for a PTSD diagnosis compared to 29% in the active-placebo control group.

Depressed mothers provided less support to their child, influencing the child’s IQ. The reverse effect, where children’s IQ affected maternal depression, was also seen.

Transgender/gender-nonconforming youth may present with mental health conditions that require immediate evaluation and implementation gender identity support measures.

The NDA acceptance comes just days after the FDA issued a Refusal to File letter to Alkermes for its investigational MDD therapy.

Investigators noted promising results for secondary outcomes but demonstrated no difference for the primary outcome of reducing hospital visits due to self-harm.

Women with PCOS face increased risk of psychiatric morbidity and their children are more likely to be diagnosed with ADHD or autism.

The FDA is requesting that additional clinical trials, along with a bioavailability study, are needed to resubmit ALKS 5461.

Depressive mood and irritability in childhood was found to double the likelihood of suicidality in adolescence.

Participants taking anti-depressants 36% more likely to develop atrial fibrillation.

Depression is often daunting for patients to go through and for their physicians to treat. About 13% of pregnant women and new mothers have depression.

The hottest subject in psychiatry right now is the clinical use of an old anesthetic (and sometimes party drug), ketamine, as the most rapidly acting and effective antidepressant the field has ever seen.

The therapy is currently approved for use by adults with bipolar depression and for the treatment of schizophrenia in patients aged 13 and older.

Following their review, the authors concluded that the SDS reports are useful in informing acute randomized placebo-controlled studies.